Signal pathways involved in contrast-induced acute kidney injury
Contrast-induced acute kidney injury (CI-AKI) has emerged as a global public health concern, ranking as the third most prevalent cause of hospital-acquired acute kidney injury, which is related to adverse outcomes. However, its precise pathogenesis remains elusive. Consequently, researchers are dedi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1490725/full |
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| author | Ke Deng Mingxin Pei Beibei Li Nanqi Yang Zijian Wang Xinchi Wan Zhiying Zhong Zhiyi Yang Yanling Chen |
| author_facet | Ke Deng Mingxin Pei Beibei Li Nanqi Yang Zijian Wang Xinchi Wan Zhiying Zhong Zhiyi Yang Yanling Chen |
| author_sort | Ke Deng |
| collection | DOAJ |
| description | Contrast-induced acute kidney injury (CI-AKI) has emerged as a global public health concern, ranking as the third most prevalent cause of hospital-acquired acute kidney injury, which is related to adverse outcomes. However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated to uncovering CI-AKI’s pathophysiology and signaling pathways, including inflammation, oxidative stress, apoptosis, and ferroptosis, to improve prevention and treatment. This review thoroughly analyzes the signaling pathways and their interactions associated with CI-AKI, assesses the impact of various research models on pathway analysis, and explores more precise targeted treatment and prevention approaches. Aims to furnish a robust theoretical foundation for the molecular mechanisms underpinning clinical treatments. |
| format | Article |
| id | doaj-art-3c2de2b4885b49b4b812bc9588544304 |
| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-3c2de2b4885b49b4b812bc95885443042024-11-25T06:24:06ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-11-011510.3389/fphys.2024.14907251490725Signal pathways involved in contrast-induced acute kidney injuryKe DengMingxin PeiBeibei LiNanqi YangZijian WangXinchi WanZhiying ZhongZhiyi YangYanling ChenContrast-induced acute kidney injury (CI-AKI) has emerged as a global public health concern, ranking as the third most prevalent cause of hospital-acquired acute kidney injury, which is related to adverse outcomes. However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated to uncovering CI-AKI’s pathophysiology and signaling pathways, including inflammation, oxidative stress, apoptosis, and ferroptosis, to improve prevention and treatment. This review thoroughly analyzes the signaling pathways and their interactions associated with CI-AKI, assesses the impact of various research models on pathway analysis, and explores more precise targeted treatment and prevention approaches. Aims to furnish a robust theoretical foundation for the molecular mechanisms underpinning clinical treatments.https://www.frontiersin.org/articles/10.3389/fphys.2024.1490725/fullcontrast-induced acute kidney injurysignal pathwaysoxidative stressinflammationapoptosisferroptosis |
| spellingShingle | Ke Deng Mingxin Pei Beibei Li Nanqi Yang Zijian Wang Xinchi Wan Zhiying Zhong Zhiyi Yang Yanling Chen Signal pathways involved in contrast-induced acute kidney injury Frontiers in Physiology contrast-induced acute kidney injury signal pathways oxidative stress inflammation apoptosis ferroptosis |
| title | Signal pathways involved in contrast-induced acute kidney injury |
| title_full | Signal pathways involved in contrast-induced acute kidney injury |
| title_fullStr | Signal pathways involved in contrast-induced acute kidney injury |
| title_full_unstemmed | Signal pathways involved in contrast-induced acute kidney injury |
| title_short | Signal pathways involved in contrast-induced acute kidney injury |
| title_sort | signal pathways involved in contrast induced acute kidney injury |
| topic | contrast-induced acute kidney injury signal pathways oxidative stress inflammation apoptosis ferroptosis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1490725/full |
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