mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae
Abstract Plasmodium, the causative agents of malaria, are obtained by mosquitoes from an infected human. Following Plasmodium acquisition by Anopheles gambiae, mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT) plays a critical role in its subsequent sporogony in the mosquito. A...
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| Format: | Article |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-55902-1 |
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| author | Brady Dolan Tomás Correa Gaviria Yuemei Dong Peter Cresswell George Dimopoulos Yu-Min Chuang Erol Fikrig |
| author_facet | Brady Dolan Tomás Correa Gaviria Yuemei Dong Peter Cresswell George Dimopoulos Yu-Min Chuang Erol Fikrig |
| author_sort | Brady Dolan |
| collection | DOAJ |
| description | Abstract Plasmodium, the causative agents of malaria, are obtained by mosquitoes from an infected human. Following Plasmodium acquisition by Anopheles gambiae, mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT) plays a critical role in its subsequent sporogony in the mosquito. A critical location for this development is the midgut, a tissue we show expresses mosGILT. Using membrane-feeding and murine infection models, we demonstrate that antibodies against mosGILT reduce the number of P. falciparum and P. berghei oocysts in the midgut and the infection prevalence of both species in the mosquito. mosGILT antibodies act in the mosquito midgut, specifically impacting the Plasmodium oocyst stage. Targeting mosGILT can therefore interfere with the Plasmodium life cycle in the mosquito and potentially serve as a transmission-blocking vaccine. |
| format | Article |
| id | doaj-art-3c263321b9af4bae8cacd109e1b14648 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-3c263321b9af4bae8cacd109e1b146482025-01-12T12:31:29ZengNature PortfolioNature Communications2041-17232025-01-0116111310.1038/s41467-025-55902-1mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiaeBrady Dolan0Tomás Correa Gaviria1Yuemei Dong2Peter Cresswell3George Dimopoulos4Yu-Min Chuang5Erol Fikrig6Section of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversityDepartment of Immunobiology, Yale University School of MedicineW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversitySection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineSection of Infectious Diseases, Department of Internal Medicine, Yale University School of MedicineAbstract Plasmodium, the causative agents of malaria, are obtained by mosquitoes from an infected human. Following Plasmodium acquisition by Anopheles gambiae, mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT) plays a critical role in its subsequent sporogony in the mosquito. A critical location for this development is the midgut, a tissue we show expresses mosGILT. Using membrane-feeding and murine infection models, we demonstrate that antibodies against mosGILT reduce the number of P. falciparum and P. berghei oocysts in the midgut and the infection prevalence of both species in the mosquito. mosGILT antibodies act in the mosquito midgut, specifically impacting the Plasmodium oocyst stage. Targeting mosGILT can therefore interfere with the Plasmodium life cycle in the mosquito and potentially serve as a transmission-blocking vaccine.https://doi.org/10.1038/s41467-025-55902-1 |
| spellingShingle | Brady Dolan Tomás Correa Gaviria Yuemei Dong Peter Cresswell George Dimopoulos Yu-Min Chuang Erol Fikrig mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae Nature Communications |
| title | mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae |
| title_full | mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae |
| title_fullStr | mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae |
| title_full_unstemmed | mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae |
| title_short | mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae |
| title_sort | mosgilt antibodies interfere with plasmodium sporogony in anopheles gambiae |
| url | https://doi.org/10.1038/s41467-025-55902-1 |
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