Use of the oxygen reserve index/FiO2 as a non-invasive index to estimate venous admixture in anesthetized dogs
The oxygen reserve index (ORi) is a novel, non-invasive parameter that estimates arterial oxygen partial pressure (PaO2) during hyperoxia when the fraction of inspired oxygen (FiO2) is elevated. This study aimed to assess the utility of the ORi/FiO2 ratio as an index for quantifying F-shunt, serving...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1495543/full |
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| author | Luca Bellini Jill K. Maney Francesca Zanusso Brighton T. Dzikiti |
| author_facet | Luca Bellini Jill K. Maney Francesca Zanusso Brighton T. Dzikiti |
| author_sort | Luca Bellini |
| collection | DOAJ |
| description | The oxygen reserve index (ORi) is a novel, non-invasive parameter that estimates arterial oxygen partial pressure (PaO2) during hyperoxia when the fraction of inspired oxygen (FiO2) is elevated. This study aimed to assess the utility of the ORi/FiO2 ratio as an index for quantifying F-shunt, serving as an estimate of venous admixture. Anesthetic records were reviewed from 44 dogs undergoing general anesthesia and requiring arterial catheterization. ORi was measured via a CO-oximeter using a probe on the tongue. Paired measurements of PaO2, obtained by blood gas analysis, and ORi were taken at various FiO2 levels to achieve an ORi between 0 and 1. Venous admixture was quantified by F-shunt. Spearman’s correlation coefficient assessed the relationship between ORi/FiO2 and F-shunt. Youden’s index identified the optimal cut-off point to predict a physiological F-shunt (≤ 10%). A total of 77 paired observations were collected, revealing a moderate negative correlation between F-shunt and ORi/FiO2 (rho = −0.59, p < 0.001). An ORi/FiO2 cut-off of 1.2 demonstrated 80% sensitivity for identifying dogs with an F-shunt ≤10%, with a ROC curve area above 80%. However, the index was less effective at distinguishing dogs with higher shunt fractions. The ORi/FiO2 index identifies dogs with low F-shunt during anesthesia with strong sensitivity and predictive accuracy, potentially ruling out the occurrence of ventilation-perfusion inequality. However, it cannot replace blood gas analysis for quantifying venous admixture. |
| format | Article |
| id | doaj-art-3c10910422f84f6fb4acfb1e20234a2e |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Veterinary Science |
| spelling | doaj-art-3c10910422f84f6fb4acfb1e20234a2e2025-01-06T05:13:25ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.14955431495543Use of the oxygen reserve index/FiO2 as a non-invasive index to estimate venous admixture in anesthetized dogsLuca Bellini0Jill K. Maney1Francesca Zanusso2Brighton T. Dzikiti3Department of Animal Medicine, Production and Health, University of Padova, Padova, ItalyDepartment of Clinical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and NevisDepartment of Animal Medicine, Production and Health, University of Padova, Padova, ItalyDepartment of Clinical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and NevisThe oxygen reserve index (ORi) is a novel, non-invasive parameter that estimates arterial oxygen partial pressure (PaO2) during hyperoxia when the fraction of inspired oxygen (FiO2) is elevated. This study aimed to assess the utility of the ORi/FiO2 ratio as an index for quantifying F-shunt, serving as an estimate of venous admixture. Anesthetic records were reviewed from 44 dogs undergoing general anesthesia and requiring arterial catheterization. ORi was measured via a CO-oximeter using a probe on the tongue. Paired measurements of PaO2, obtained by blood gas analysis, and ORi were taken at various FiO2 levels to achieve an ORi between 0 and 1. Venous admixture was quantified by F-shunt. Spearman’s correlation coefficient assessed the relationship between ORi/FiO2 and F-shunt. Youden’s index identified the optimal cut-off point to predict a physiological F-shunt (≤ 10%). A total of 77 paired observations were collected, revealing a moderate negative correlation between F-shunt and ORi/FiO2 (rho = −0.59, p < 0.001). An ORi/FiO2 cut-off of 1.2 demonstrated 80% sensitivity for identifying dogs with an F-shunt ≤10%, with a ROC curve area above 80%. However, the index was less effective at distinguishing dogs with higher shunt fractions. The ORi/FiO2 index identifies dogs with low F-shunt during anesthesia with strong sensitivity and predictive accuracy, potentially ruling out the occurrence of ventilation-perfusion inequality. However, it cannot replace blood gas analysis for quantifying venous admixture.https://www.frontiersin.org/articles/10.3389/fvets.2024.1495543/fullF-shuntdogsoxygen reserve indexanesthesiablood gas analysis |
| spellingShingle | Luca Bellini Jill K. Maney Francesca Zanusso Brighton T. Dzikiti Use of the oxygen reserve index/FiO2 as a non-invasive index to estimate venous admixture in anesthetized dogs Frontiers in Veterinary Science F-shunt dogs oxygen reserve index anesthesia blood gas analysis |
| title | Use of the oxygen reserve index/FiO2 as a non-invasive index to estimate venous admixture in anesthetized dogs |
| title_full | Use of the oxygen reserve index/FiO2 as a non-invasive index to estimate venous admixture in anesthetized dogs |
| title_fullStr | Use of the oxygen reserve index/FiO2 as a non-invasive index to estimate venous admixture in anesthetized dogs |
| title_full_unstemmed | Use of the oxygen reserve index/FiO2 as a non-invasive index to estimate venous admixture in anesthetized dogs |
| title_short | Use of the oxygen reserve index/FiO2 as a non-invasive index to estimate venous admixture in anesthetized dogs |
| title_sort | use of the oxygen reserve index fio2 as a non invasive index to estimate venous admixture in anesthetized dogs |
| topic | F-shunt dogs oxygen reserve index anesthesia blood gas analysis |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1495543/full |
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