Delayed modulation of alpha band activity increases response inhibition deficits in adolescents with AD(H)D
Deficiencies in inhibitory control are one of the hallmarks of attention-deficit-(hyperactivity) disorder (AD(H)D). Response inhibition demands can become increased through additional conflicts, namely when already integrated representations of perception–action associations have to be updated. Yet,...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158224001189 |
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| author | Katharina Graf Roula Jamous Moritz Mückschel Annet Bluschke Christian Beste |
| author_facet | Katharina Graf Roula Jamous Moritz Mückschel Annet Bluschke Christian Beste |
| author_sort | Katharina Graf |
| collection | DOAJ |
| description | Deficiencies in inhibitory control are one of the hallmarks of attention-deficit-(hyperactivity) disorder (AD(H)D). Response inhibition demands can become increased through additional conflicts, namely when already integrated representations of perception–action associations have to be updated. Yet, the neural mechanisms of how such conflicts worsen response inhibition in AD(H)D are unknown, but, if identified, could help to better understand the complex nature of AD(H)D-associated impulsivity. We investigated both behavioral performance and EEG activity in the theta and alpha band of adolescents (10–18 years of age) with AD(H)D (n = 28) compared to neurotypical (NT) controls (n = 33) in a conflict-modulated Go/Nogo paradigm. We used multivariate pattern analysis (MVPA) and EEG-beamforming to examine how changes in representational content are coded by oscillatory activity and to delineate the cortical structures involved in it. The presented behavioral and neurophysiological data show that adolescents with AD(H)D are more strongly affected by increased response inhibition demands through additional conflicts than NT controls. Precisely, AD(H)D participants showed higher false alarm rates than NT controls in both, non-overlapping and overlapping Nogo trials, but performed even worse in the latter. This is likely due to an inefficient updating of representations related to delayed modulations of alpha band activity in the ventral stream and orbitofrontal regions. Theta band activity is also modulated by conflict but was not differentially affected in the two groups. By this, the present study provides novel insights into underlying neurophysiological mechanisms of the complex nature of response inhibition deficits in adolescents with AD(H)D, stressing the importance to examine the interplay of theta and alpha band activity more closely to better understand inhibitory control deficits in AD(H)D. |
| format | Article |
| id | doaj-art-3c105bcd3ee64de28acd4f57b0aeaa0c |
| institution | Kabale University |
| issn | 2213-1582 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-3c105bcd3ee64de28acd4f57b0aeaa0c2024-11-29T06:23:40ZengElsevierNeuroImage: Clinical2213-15822024-01-0144103677Delayed modulation of alpha band activity increases response inhibition deficits in adolescents with AD(H)DKatharina Graf0Roula Jamous1Moritz Mückschel2Annet Bluschke3Christian Beste4Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU, Dresden, GermanyCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU, Dresden, GermanyCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU, Dresden, GermanyCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU, Dresden, GermanyCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU, Dresden, Germany; Corresponding author at: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.Deficiencies in inhibitory control are one of the hallmarks of attention-deficit-(hyperactivity) disorder (AD(H)D). Response inhibition demands can become increased through additional conflicts, namely when already integrated representations of perception–action associations have to be updated. Yet, the neural mechanisms of how such conflicts worsen response inhibition in AD(H)D are unknown, but, if identified, could help to better understand the complex nature of AD(H)D-associated impulsivity. We investigated both behavioral performance and EEG activity in the theta and alpha band of adolescents (10–18 years of age) with AD(H)D (n = 28) compared to neurotypical (NT) controls (n = 33) in a conflict-modulated Go/Nogo paradigm. We used multivariate pattern analysis (MVPA) and EEG-beamforming to examine how changes in representational content are coded by oscillatory activity and to delineate the cortical structures involved in it. The presented behavioral and neurophysiological data show that adolescents with AD(H)D are more strongly affected by increased response inhibition demands through additional conflicts than NT controls. Precisely, AD(H)D participants showed higher false alarm rates than NT controls in both, non-overlapping and overlapping Nogo trials, but performed even worse in the latter. This is likely due to an inefficient updating of representations related to delayed modulations of alpha band activity in the ventral stream and orbitofrontal regions. Theta band activity is also modulated by conflict but was not differentially affected in the two groups. By this, the present study provides novel insights into underlying neurophysiological mechanisms of the complex nature of response inhibition deficits in adolescents with AD(H)D, stressing the importance to examine the interplay of theta and alpha band activity more closely to better understand inhibitory control deficits in AD(H)D.http://www.sciencedirect.com/science/article/pii/S2213158224001189ADHDResponse inhibitionEEGTheta band activityAlpha band activityMVPA |
| spellingShingle | Katharina Graf Roula Jamous Moritz Mückschel Annet Bluschke Christian Beste Delayed modulation of alpha band activity increases response inhibition deficits in adolescents with AD(H)D NeuroImage: Clinical ADHD Response inhibition EEG Theta band activity Alpha band activity MVPA |
| title | Delayed modulation of alpha band activity increases response inhibition deficits in adolescents with AD(H)D |
| title_full | Delayed modulation of alpha band activity increases response inhibition deficits in adolescents with AD(H)D |
| title_fullStr | Delayed modulation of alpha band activity increases response inhibition deficits in adolescents with AD(H)D |
| title_full_unstemmed | Delayed modulation of alpha band activity increases response inhibition deficits in adolescents with AD(H)D |
| title_short | Delayed modulation of alpha band activity increases response inhibition deficits in adolescents with AD(H)D |
| title_sort | delayed modulation of alpha band activity increases response inhibition deficits in adolescents with ad h d |
| topic | ADHD Response inhibition EEG Theta band activity Alpha band activity MVPA |
| url | http://www.sciencedirect.com/science/article/pii/S2213158224001189 |
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