Predictive value of NT-pro BNP on outcomes of children with ventricular septal defect surgery
BackgroundLimited study has shown whether NT-proBNP is related to the prognosis of children wth ventricular septal defect (VSD) surgery. The study was conducted to determine the predictive value of NT-proBNP on outcomes of children with VSD surgery.MethodsA total of 798 children with VSD surgery wer...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1454371/full |
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| author | Weidan Chen Yajie Tang Ye Lu Li Ma Xinxin Chen Techang Liu |
| author_facet | Weidan Chen Yajie Tang Ye Lu Li Ma Xinxin Chen Techang Liu |
| author_sort | Weidan Chen |
| collection | DOAJ |
| description | BackgroundLimited study has shown whether NT-proBNP is related to the prognosis of children wth ventricular septal defect (VSD) surgery. The study was conducted to determine the predictive value of NT-proBNP on outcomes of children with VSD surgery.MethodsA total of 798 children with VSD surgery were enrolled, with NT-proBNP measured at preoperatively and 24-h postoperatively. The short- and mid-term clinical outcomes were recorded. Propensity scores (PS) was performed to acquire pre-op and post NT-proBNP 24-h PS-matched cohorts for comparisons between groups.ResultsIn the pre NT-proBNP PS-matched cohort, the higher NT pro-BNP group had longer hospitalization time and lower post-op 1-month EF value compared with low NT pro-BNP group (all P < 0.05), and there wasn't significant difference of mechanical ventilation time, cardiopulmonary bypass (CPB) time, intensive care unit (CCU) stay, and ejection fraction (EF) values of 3 month to 12 months after surgery (all P > 0.05). In the post NT-proBNP PS-matched cohort, there wasn't significant difference of mechanical ventilation time, CPB time, CCU stay, hospitalization time, and EF values of 1 month to 12 months after surgery between two groups (all P > 0.05).ConclusionsVSD children with higher pre NT-proBNP level had longer hospital stays after surgery than those with lower level. Pre NT-proBNP level had no effect on mechanical ventilation time, CPB time, ACC time and CCU stay and cardiac function after 3 months postoperatively. Post-op 24-h NT pro-BNP level wasn't associated with clinical outcomes. |
| format | Article |
| id | doaj-art-3c0bd712430448f48de80afe58476c19 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-3c0bd712430448f48de80afe58476c192025-01-15T13:45:12ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.14543711454371Predictive value of NT-pro BNP on outcomes of children with ventricular septal defect surgeryWeidan Chen0Yajie Tang1Ye Lu2Li Ma3Xinxin Chen4Techang Liu5Cardiovascular Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaDepartment of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCardiovascular Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaCardiovascular Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaCardiovascular Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaCardiovascular Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaBackgroundLimited study has shown whether NT-proBNP is related to the prognosis of children wth ventricular septal defect (VSD) surgery. The study was conducted to determine the predictive value of NT-proBNP on outcomes of children with VSD surgery.MethodsA total of 798 children with VSD surgery were enrolled, with NT-proBNP measured at preoperatively and 24-h postoperatively. The short- and mid-term clinical outcomes were recorded. Propensity scores (PS) was performed to acquire pre-op and post NT-proBNP 24-h PS-matched cohorts for comparisons between groups.ResultsIn the pre NT-proBNP PS-matched cohort, the higher NT pro-BNP group had longer hospitalization time and lower post-op 1-month EF value compared with low NT pro-BNP group (all P < 0.05), and there wasn't significant difference of mechanical ventilation time, cardiopulmonary bypass (CPB) time, intensive care unit (CCU) stay, and ejection fraction (EF) values of 3 month to 12 months after surgery (all P > 0.05). In the post NT-proBNP PS-matched cohort, there wasn't significant difference of mechanical ventilation time, CPB time, CCU stay, hospitalization time, and EF values of 1 month to 12 months after surgery between two groups (all P > 0.05).ConclusionsVSD children with higher pre NT-proBNP level had longer hospital stays after surgery than those with lower level. Pre NT-proBNP level had no effect on mechanical ventilation time, CPB time, ACC time and CCU stay and cardiac function after 3 months postoperatively. Post-op 24-h NT pro-BNP level wasn't associated with clinical outcomes.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1454371/fullventricular septal defectchildrenNT-pro BNPNT-proBNPpredictive valueclinical outcomes |
| spellingShingle | Weidan Chen Yajie Tang Ye Lu Li Ma Xinxin Chen Techang Liu Predictive value of NT-pro BNP on outcomes of children with ventricular septal defect surgery Frontiers in Cardiovascular Medicine ventricular septal defect children NT-pro BNPNT-proBNP predictive value clinical outcomes |
| title | Predictive value of NT-pro BNP on outcomes of children with ventricular septal defect surgery |
| title_full | Predictive value of NT-pro BNP on outcomes of children with ventricular septal defect surgery |
| title_fullStr | Predictive value of NT-pro BNP on outcomes of children with ventricular septal defect surgery |
| title_full_unstemmed | Predictive value of NT-pro BNP on outcomes of children with ventricular septal defect surgery |
| title_short | Predictive value of NT-pro BNP on outcomes of children with ventricular septal defect surgery |
| title_sort | predictive value of nt pro bnp on outcomes of children with ventricular septal defect surgery |
| topic | ventricular septal defect children NT-pro BNPNT-proBNP predictive value clinical outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1454371/full |
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