Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients
Abstract Background Autoimmune thyroid diseases (AITD) and allergic rhinitis (AR) are prevalent conditions; however, limited research has investigated their association. This study aimed to evaluate whether AR can be considered a risk factor for developing AITD. Methods A retrospective cohort study...
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BMC
2024-12-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01685-3 |
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| author | Magdy Mohamed Allam Soha Magdy Ahmed Dalia Khamis El-Deeb Ahmed Yassin Bahgat Ramy Mohamed Ghazy Hanaa Tarek El-Zawawy |
| author_facet | Magdy Mohamed Allam Soha Magdy Ahmed Dalia Khamis El-Deeb Ahmed Yassin Bahgat Ramy Mohamed Ghazy Hanaa Tarek El-Zawawy |
| author_sort | Magdy Mohamed Allam |
| collection | DOAJ |
| description | Abstract Background Autoimmune thyroid diseases (AITD) and allergic rhinitis (AR) are prevalent conditions; however, limited research has investigated their association. This study aimed to evaluate whether AR can be considered a risk factor for developing AITD. Methods A retrospective cohort study analyzed the records of AITD patients who visited Alexandria University Students Hospital between January 2017 and December 2021. The parameters included in the study were thyroid-stimulating hormone (TSH), Free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibodies (TPOAb), thyrotropin receptor antibody (TRAb), eosinophils count, and IgE. Results Out of 4,515 eligible patients, 41.7% were diagnosed with AR in addition to AITD. Among the patients with both conditions, 81% were females, their mean age was 45.71 ± 24.14 years, and the mean duration of AITD was 7.32 ± 2.11 years. The Kaplan–Meier analysis revealed that the AR cohort had a higher cumulative incidence of AITD than did the non-AR cohort (log-rank test, p = 0.001). Multivariate-adjusted hazardous ratios showed that patients with AR, female sex, higher white blood cell count, and diagnosis in November had a higher risk of developing AITD. Conclusions Screening for AITD should be conducted at the time of diagnosis of AR as it could be a risk factor for AITD. |
| format | Article |
| id | doaj-art-3c036ab6c4234fc18b8203e850390290 |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-3c036ab6c4234fc18b8203e8503902902025-01-05T12:33:01ZengBMCBMC Endocrine Disorders1472-68232024-12-0124111010.1186/s12902-024-01685-3Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patientsMagdy Mohamed Allam0Soha Magdy Ahmed1Dalia Khamis El-Deeb2Ahmed Yassin Bahgat3Ramy Mohamed Ghazy4Hanaa Tarek El-Zawawy5Internal Medicine Department, Endocrinology Division, Alexandria University Student Hospital (AUSH), Alexandria UniversityInternal Medicine Department, Alexandria University Student Hospital (AUSH), Alexandria UniversityCommunity Medicine Department, Faculty of Medicine, Alexandria UniversityOto-rhino-laryngology Department, Faculty of Medicine, Alexandria UniversityTropical Health Department, High Institute of Public Health, Alexandria UniversityInternal Medicine Department, Endocrinology Unit, Faculty of Medicine, Alexandria UniversityAbstract Background Autoimmune thyroid diseases (AITD) and allergic rhinitis (AR) are prevalent conditions; however, limited research has investigated their association. This study aimed to evaluate whether AR can be considered a risk factor for developing AITD. Methods A retrospective cohort study analyzed the records of AITD patients who visited Alexandria University Students Hospital between January 2017 and December 2021. The parameters included in the study were thyroid-stimulating hormone (TSH), Free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibodies (TPOAb), thyrotropin receptor antibody (TRAb), eosinophils count, and IgE. Results Out of 4,515 eligible patients, 41.7% were diagnosed with AR in addition to AITD. Among the patients with both conditions, 81% were females, their mean age was 45.71 ± 24.14 years, and the mean duration of AITD was 7.32 ± 2.11 years. The Kaplan–Meier analysis revealed that the AR cohort had a higher cumulative incidence of AITD than did the non-AR cohort (log-rank test, p = 0.001). Multivariate-adjusted hazardous ratios showed that patients with AR, female sex, higher white blood cell count, and diagnosis in November had a higher risk of developing AITD. Conclusions Screening for AITD should be conducted at the time of diagnosis of AR as it could be a risk factor for AITD.https://doi.org/10.1186/s12902-024-01685-3Allergic rhinitisAutoimmune thyroid diseasesGraves` diseaseHashimoto’s thyroiditisHypothyroidismHyperthyroidism |
| spellingShingle | Magdy Mohamed Allam Soha Magdy Ahmed Dalia Khamis El-Deeb Ahmed Yassin Bahgat Ramy Mohamed Ghazy Hanaa Tarek El-Zawawy Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients BMC Endocrine Disorders Allergic rhinitis Autoimmune thyroid diseases Graves` disease Hashimoto’s thyroiditis Hypothyroidism Hyperthyroidism |
| title | Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients |
| title_full | Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients |
| title_fullStr | Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients |
| title_full_unstemmed | Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients |
| title_short | Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients |
| title_sort | association between allergic rhinitis and development of autoimmune thyroid diseases in egyptian patients |
| topic | Allergic rhinitis Autoimmune thyroid diseases Graves` disease Hashimoto’s thyroiditis Hypothyroidism Hyperthyroidism |
| url | https://doi.org/10.1186/s12902-024-01685-3 |
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