Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results
Purpose Since 2016, the multicase-control study in Spain (MCC-Spain) has focused towards the identification of factors associated with cancer prognosis. Inception cohorts of patients with colorectal, breast and prostate cancers were assembled using the incident cases originally recruited.Participant...
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BMJ Publishing Group
2019-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/11/e031904.full |
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| author | Silvia De Sanjosé Manolis Kogevinas Gemma Castano-Vinyals Maria Dolores Chirlaque Victor Moreno Jessica Alonso-Molero Antonio J Molina Jose Juan Jiménez-Moleón Beatriz Pérez-Gómez Vicente Martin Pilar Amiano Eva Ardanaz Inmaculada Salcedo Guillermo Fernandez-Tardon Juan Alguacil Dolores Salas Rafael Marcos-Gragera Nuria Aragonés Marina Pollán Javier Llorca |
| author_facet | Silvia De Sanjosé Manolis Kogevinas Gemma Castano-Vinyals Maria Dolores Chirlaque Victor Moreno Jessica Alonso-Molero Antonio J Molina Jose Juan Jiménez-Moleón Beatriz Pérez-Gómez Vicente Martin Pilar Amiano Eva Ardanaz Inmaculada Salcedo Guillermo Fernandez-Tardon Juan Alguacil Dolores Salas Rafael Marcos-Gragera Nuria Aragonés Marina Pollán Javier Llorca |
| author_sort | Silvia De Sanjosé |
| collection | DOAJ |
| description | Purpose Since 2016, the multicase-control study in Spain (MCC-Spain) has focused towards the identification of factors associated with cancer prognosis. Inception cohorts of patients with colorectal, breast and prostate cancers were assembled using the incident cases originally recruited.Participants 2140 new cases of colorectal cancer, 1732 of breast cancer and 1112 of prostate cancer were initially recruited in 12 Spanish provinces; all cancers were incident and pathologically confirmed. Follow-up was obtained for 2097 (98%), 1685 (97%) and 1055 (94.9%) patients, respectively.Findings to date Information gathered at recruitment included sociodemographic factors, medical history, lifestyle and environmental exposures. Biological samples were obtained, and 80% of patients were genotyped using a commercial exome array. The follow-up was performed by (1) reviewing medical records; (2) interviewing the patients by phone on quality of life; and (3) verifying vital status and cause of death in the Spanish National Death Index. Ninety-seven per cent of recruited patients were successfully followed up in 2017 or 2018; patient-years of follow-up were 30 914. Most colorectal cancers (52%) were at clinical stage II or lower at recruitment; 819 patients died in the follow-up and the 5-year survival was better for women (74.4%) than men (70.0%). 71% of breast cancers were diagnosed at stages I or II; 206 women with breast cancer died in the follow-up and the 5-year survival was 90.7%. 49% of prostate cancers were diagnosed at stage II and 32% at stage III; 119 patients with prostate cancer died in the follow-up and the 5-year survival was 93.7%.Future plans MCC-Spain has built three prospective cohorts on highly frequent cancers across Spain, allowing to investigate socioeconomic, clinical, lifestyle, environmental and genetic variables as putative prognosis factors determining survival of patients of the three cancers and the inter-relationship of these factors. |
| format | Article |
| id | doaj-art-3bff834a054842daa0d9e94dce4b3b44 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-3bff834a054842daa0d9e94dce4b3b442024-11-27T17:05:07ZengBMJ Publishing GroupBMJ Open2044-60552019-11-0191110.1136/bmjopen-2019-031904Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial resultsSilvia De Sanjosé0Manolis Kogevinas1Gemma Castano-Vinyals2Maria Dolores Chirlaque3Victor Moreno4Jessica Alonso-Molero5Antonio J Molina6Jose Juan Jiménez-Moleón7Beatriz Pérez-Gómez8Vicente Martin9Pilar Amiano10Eva Ardanaz11Inmaculada Salcedo12Guillermo Fernandez-Tardon13Juan Alguacil14Dolores Salas15Rafael Marcos-Gragera16Nuria Aragonés17Marina Pollán18Javier Llorca199 Sexual and Reproductive Health, PATH, Seattle, Washington, USA3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Granada, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, SpainUniversity of Cantabria – IDIVAL, Santander, SpainGrupo de Investigación en Interacciones Gen-Ambiente y Salud (GIIGAS), Instituto de Biomedicina (IBIOMED), Universidad de León, León, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Granada, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Granada, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), University of Oviedo, CIBERESP, Madrid, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Granada, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, Spain3 Consortium for Biomedical Research in Epidemiology and Public Health, CIBERESP, Madrid, SpainPurpose Since 2016, the multicase-control study in Spain (MCC-Spain) has focused towards the identification of factors associated with cancer prognosis. Inception cohorts of patients with colorectal, breast and prostate cancers were assembled using the incident cases originally recruited.Participants 2140 new cases of colorectal cancer, 1732 of breast cancer and 1112 of prostate cancer were initially recruited in 12 Spanish provinces; all cancers were incident and pathologically confirmed. Follow-up was obtained for 2097 (98%), 1685 (97%) and 1055 (94.9%) patients, respectively.Findings to date Information gathered at recruitment included sociodemographic factors, medical history, lifestyle and environmental exposures. Biological samples were obtained, and 80% of patients were genotyped using a commercial exome array. The follow-up was performed by (1) reviewing medical records; (2) interviewing the patients by phone on quality of life; and (3) verifying vital status and cause of death in the Spanish National Death Index. Ninety-seven per cent of recruited patients were successfully followed up in 2017 or 2018; patient-years of follow-up were 30 914. Most colorectal cancers (52%) were at clinical stage II or lower at recruitment; 819 patients died in the follow-up and the 5-year survival was better for women (74.4%) than men (70.0%). 71% of breast cancers were diagnosed at stages I or II; 206 women with breast cancer died in the follow-up and the 5-year survival was 90.7%. 49% of prostate cancers were diagnosed at stage II and 32% at stage III; 119 patients with prostate cancer died in the follow-up and the 5-year survival was 93.7%.Future plans MCC-Spain has built three prospective cohorts on highly frequent cancers across Spain, allowing to investigate socioeconomic, clinical, lifestyle, environmental and genetic variables as putative prognosis factors determining survival of patients of the three cancers and the inter-relationship of these factors.https://bmjopen.bmj.com/content/9/11/e031904.full |
| spellingShingle | Silvia De Sanjosé Manolis Kogevinas Gemma Castano-Vinyals Maria Dolores Chirlaque Victor Moreno Jessica Alonso-Molero Antonio J Molina Jose Juan Jiménez-Moleón Beatriz Pérez-Gómez Vicente Martin Pilar Amiano Eva Ardanaz Inmaculada Salcedo Guillermo Fernandez-Tardon Juan Alguacil Dolores Salas Rafael Marcos-Gragera Nuria Aragonés Marina Pollán Javier Llorca Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results BMJ Open |
| title | Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results |
| title_full | Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results |
| title_fullStr | Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results |
| title_full_unstemmed | Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results |
| title_short | Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results |
| title_sort | cohort profile the mcc spain follow up on colorectal breast and prostate cancers study design and initial results |
| url | https://bmjopen.bmj.com/content/9/11/e031904.full |
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