Multi-modal integration of MRI and global chamber charge density mapping for the evaluation of atrial fibrillation
Atrial fibrillation (AF) is the most prevalent clinical arrhythmia, posing significant mortality and morbidity challenges. Outcomes of current catheter ablation treatment strategies are suboptimal, highlighting the need for innovative approaches. A major obstacle lies in the inability to comprehensi...
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| Language: | English |
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The Royal Society
2025-01-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.241048 |
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| author | Alexander J. Sharp Michael T. B. Pope Andre Briosa e Gala Richard Varini Timothy R. Betts Abhirup Banerjee |
| author_facet | Alexander J. Sharp Michael T. B. Pope Andre Briosa e Gala Richard Varini Timothy R. Betts Abhirup Banerjee |
| author_sort | Alexander J. Sharp |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most prevalent clinical arrhythmia, posing significant mortality and morbidity challenges. Outcomes of current catheter ablation treatment strategies are suboptimal, highlighting the need for innovative approaches. A major obstacle lies in the inability to comprehensively assess both structural and functional remodelling in AF. Combining magnetic resonance imaging (MRI)’s detailed structural insights with global chamber charge density mapping (CDM)’s functional mapping capabilities holds promise for advancing AF management. Our research introduces a novel tool for three-dimensional reconstruction of left atrial geometries from MRI, facilitating integration into CDM systems. We comprehensively assess our tool by generating three-dimensional left atrial meshes from MRIs of eight patients with AF and compare them with the established CDM intra-chamber ultrasound approach utilizing both geometric and clinical parameters. We apply the CDM inverse algorithm to both sets of reconstructions in order to compare derived conductions across various heart rhythms and AF conduction patterns. Finally, we explore the potential utility of our integrated pipeline through an exploration of the relationship between AF conduction patterns and their proximity to adjacent thoracic structures. Ultimately, this multifaceted approach aims to unveil insights into AF mechanisms, potentially improving treatment outcomes through personalized ablation strategies targeting arrhythmogenic atrial substrate. |
| format | Article |
| id | doaj-art-3be4b77b3ce844d4854f871dec08936d |
| institution | Kabale University |
| issn | 2054-5703 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj-art-3be4b77b3ce844d4854f871dec08936d2025-01-15T00:06:00ZengThe Royal SocietyRoyal Society Open Science2054-57032025-01-0112110.1098/rsos.241048Multi-modal integration of MRI and global chamber charge density mapping for the evaluation of atrial fibrillationAlexander J. Sharp0Michael T. B. Pope1Andre Briosa e Gala2Richard Varini3Timothy R. Betts4Abhirup Banerjee5Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UKCardiology Department, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UKCardiology Department, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UKCardiology Department, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UKCardiology Department, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UKInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UKAtrial fibrillation (AF) is the most prevalent clinical arrhythmia, posing significant mortality and morbidity challenges. Outcomes of current catheter ablation treatment strategies are suboptimal, highlighting the need for innovative approaches. A major obstacle lies in the inability to comprehensively assess both structural and functional remodelling in AF. Combining magnetic resonance imaging (MRI)’s detailed structural insights with global chamber charge density mapping (CDM)’s functional mapping capabilities holds promise for advancing AF management. Our research introduces a novel tool for three-dimensional reconstruction of left atrial geometries from MRI, facilitating integration into CDM systems. We comprehensively assess our tool by generating three-dimensional left atrial meshes from MRIs of eight patients with AF and compare them with the established CDM intra-chamber ultrasound approach utilizing both geometric and clinical parameters. We apply the CDM inverse algorithm to both sets of reconstructions in order to compare derived conductions across various heart rhythms and AF conduction patterns. Finally, we explore the potential utility of our integrated pipeline through an exploration of the relationship between AF conduction patterns and their proximity to adjacent thoracic structures. Ultimately, this multifaceted approach aims to unveil insights into AF mechanisms, potentially improving treatment outcomes through personalized ablation strategies targeting arrhythmogenic atrial substrate.https://royalsocietypublishing.org/doi/10.1098/rsos.241048atrial fibrillationatrial shape modellingcharge density mappingmagnetic resonance imagingthree-dimensional reconstruction |
| spellingShingle | Alexander J. Sharp Michael T. B. Pope Andre Briosa e Gala Richard Varini Timothy R. Betts Abhirup Banerjee Multi-modal integration of MRI and global chamber charge density mapping for the evaluation of atrial fibrillation Royal Society Open Science atrial fibrillation atrial shape modelling charge density mapping magnetic resonance imaging three-dimensional reconstruction |
| title | Multi-modal integration of MRI and global chamber charge density mapping for the evaluation of atrial fibrillation |
| title_full | Multi-modal integration of MRI and global chamber charge density mapping for the evaluation of atrial fibrillation |
| title_fullStr | Multi-modal integration of MRI and global chamber charge density mapping for the evaluation of atrial fibrillation |
| title_full_unstemmed | Multi-modal integration of MRI and global chamber charge density mapping for the evaluation of atrial fibrillation |
| title_short | Multi-modal integration of MRI and global chamber charge density mapping for the evaluation of atrial fibrillation |
| title_sort | multi modal integration of mri and global chamber charge density mapping for the evaluation of atrial fibrillation |
| topic | atrial fibrillation atrial shape modelling charge density mapping magnetic resonance imaging three-dimensional reconstruction |
| url | https://royalsocietypublishing.org/doi/10.1098/rsos.241048 |
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