Ovarian reserve in reproductive age women with type 1 diabetes
Background: Premature aging are frequently observed among individuals with type 1 diabetes. Decrease of ovarian reserve may be one of the characteristics of such process. Aims: To evaluate the ovarian reserve function in female patients of reproductive age with type 1 diabetes in comparison with hea...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2018-09-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/9480 |
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| author | Olga R. Grigoryan Natalia S. Krasnovskaya Robert K. Mikheev Elena N. Andreeva Ivan I. Dedov |
| author_facet | Olga R. Grigoryan Natalia S. Krasnovskaya Robert K. Mikheev Elena N. Andreeva Ivan I. Dedov |
| author_sort | Olga R. Grigoryan |
| collection | DOAJ |
| description | Background: Premature aging are frequently observed among individuals with type 1 diabetes. Decrease of ovarian reserve may be one of the characteristics of such process. Aims: To evaluate the ovarian reserve function in female patients of reproductive age with type 1 diabetes in comparison with healthy women. Materials and methods: This study evaluated 224 Caucasian women, age 18–37 years with type 1 diabetes and 230 healthy women of comparable age. Serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone and testosterone were compared on the 2–3 day of menstrual cycle as ovarian volume and antral follicle count (AFC). In addition, glycated hemoglobin level (HbA1c%) was evaluated. Results: We reveal statistically significant difference in following parameters in diabetic women in comparison with healthy women: AMH, AFC. But even in diabetic patients parameters remained within reference ranges. There was a pronounced negative relationship between the levels of HbA1c% and AMG. Conclusions: Ovarian reserve function parameters decrease in young women with type 1 diabetes in comparison with healthy women, but ovarian reserve parameters are in normal reference range. These findings are important in pregnancy planning consulting by gynecologists and endocrinologists. We must recommend to women with type 1 diabetes more early planning of natural pregnancy for treatment with reproductive technology in cases of prolog absence of nature pregnancy. |
| format | Article |
| id | doaj-art-3bd63d7c08e5446d89a382a843a3aec1 |
| institution | Kabale University |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-3bd63d7c08e5446d89a382a843a3aec12025-08-20T03:47:53ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782018-09-0121426427010.14341/DM94808549Ovarian reserve in reproductive age women with type 1 diabetesOlga R. Grigoryan0Natalia S. Krasnovskaya1Robert K. Mikheev2Elena N. Andreeva3Ivan I. Dedov4<p>Endocrinology Research Centre</p><p>City clinic №9</p><p>Moscow State University of Medicine and Dentistry named after A.I. Evdokimov</p><p>Endocrinology Research Centre</p><p>Endocrinology Research Centre”</p>Background: Premature aging are frequently observed among individuals with type 1 diabetes. Decrease of ovarian reserve may be one of the characteristics of such process. Aims: To evaluate the ovarian reserve function in female patients of reproductive age with type 1 diabetes in comparison with healthy women. Materials and methods: This study evaluated 224 Caucasian women, age 18–37 years with type 1 diabetes and 230 healthy women of comparable age. Serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone and testosterone were compared on the 2–3 day of menstrual cycle as ovarian volume and antral follicle count (AFC). In addition, glycated hemoglobin level (HbA1c%) was evaluated. Results: We reveal statistically significant difference in following parameters in diabetic women in comparison with healthy women: AMH, AFC. But even in diabetic patients parameters remained within reference ranges. There was a pronounced negative relationship between the levels of HbA1c% and AMG. Conclusions: Ovarian reserve function parameters decrease in young women with type 1 diabetes in comparison with healthy women, but ovarian reserve parameters are in normal reference range. These findings are important in pregnancy planning consulting by gynecologists and endocrinologists. We must recommend to women with type 1 diabetes more early planning of natural pregnancy for treatment with reproductive technology in cases of prolog absence of nature pregnancy.https://www.dia-endojournals.ru/jour/article/view/9480anti-mullerian hormoneantral folliclesovarian reservetype 1 diabetes |
| spellingShingle | Olga R. Grigoryan Natalia S. Krasnovskaya Robert K. Mikheev Elena N. Andreeva Ivan I. Dedov Ovarian reserve in reproductive age women with type 1 diabetes Сахарный диабет anti-mullerian hormone antral follicles ovarian reserve type 1 diabetes |
| title | Ovarian reserve in reproductive age women with type 1 diabetes |
| title_full | Ovarian reserve in reproductive age women with type 1 diabetes |
| title_fullStr | Ovarian reserve in reproductive age women with type 1 diabetes |
| title_full_unstemmed | Ovarian reserve in reproductive age women with type 1 diabetes |
| title_short | Ovarian reserve in reproductive age women with type 1 diabetes |
| title_sort | ovarian reserve in reproductive age women with type 1 diabetes |
| topic | anti-mullerian hormone antral follicles ovarian reserve type 1 diabetes |
| url | https://www.dia-endojournals.ru/jour/article/view/9480 |
| work_keys_str_mv | AT olgargrigoryan ovarianreserveinreproductiveagewomenwithtype1diabetes AT nataliaskrasnovskaya ovarianreserveinreproductiveagewomenwithtype1diabetes AT robertkmikheev ovarianreserveinreproductiveagewomenwithtype1diabetes AT elenanandreeva ovarianreserveinreproductiveagewomenwithtype1diabetes AT ivanidedov ovarianreserveinreproductiveagewomenwithtype1diabetes |