Natural killer cells are required for the recruitment of CD8+ T cells and the efficacy of immune checkpoint blockade in melanoma brain metastases

Natural killer cells are required for the recruitment of CD8+ T cells and the efficacy of immune checkpoint blockade in melanoma brain metastases

Background Brain metastases (BrM) affect up to 60% of patients with metastatic melanoma and are associated with poor prognosis. While combined immune checkpoint blockade of programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) demonstrates intracranial efficacy in a prop...

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Bibliographic Details
Main Authors: Marlous Hall, Jennifer Williams, Fiona Errington-Mais, Tereza Andreou, Rebecca J Brownlie, Robert J Salmond, Mihaela Lorger, Scott Gregory, Fiona James, Christopher Fife, Ashley Sunderland, Clive McKimmie, Samuel Heaton, Zarnaz Hadi, David R Westhead, Alexander Davie, Amber Emmett
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/11/e009522.full
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