Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma
Abstract The blood-brain barrier, essential for protecting the central nervous system, also restricts drug delivery to this region. Thus, delivering drugs across the blood-brain barrier is an active research area in immunology, oncology, and neurology; moreover, novel methods are urgently needed to...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Communications Materials |
| Online Access: | https://doi.org/10.1038/s43246-024-00721-y |
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| author | Nassir Mokarram Ayden Case Nadia N. Hossainy Johnathan G. Lyon Tobey J. MacDonald Ravi Bellamkonda |
| author_facet | Nassir Mokarram Ayden Case Nadia N. Hossainy Johnathan G. Lyon Tobey J. MacDonald Ravi Bellamkonda |
| author_sort | Nassir Mokarram |
| collection | DOAJ |
| description | Abstract The blood-brain barrier, essential for protecting the central nervous system, also restricts drug delivery to this region. Thus, delivering drugs across the blood-brain barrier is an active research area in immunology, oncology, and neurology; moreover, novel methods are urgently needed to expand therapeutic options for central nervous system pathologies. While previous strategies have focused on small molecules that modulate blood-brain barrier permeability or penetrate the barrier, there is an increased focus on biomedical devices—external or implanted—for improving drug delivery. Here, we review device-assisted drug delivery across the blood–brain barrier, emphasizing its application in glioblastoma, an aggressively malignant primary brain cancer in which the blood-brain barrier plays a central role. We examine the blood-brain barrier and its features in glioblastoma, emerging models for studying the blood-brain barrier, and device-assisted methods for crossing the blood-brain barrier. We conclude by presenting methods to monitor the blood-brain barrier and paradigms for combined cross-BBB drug delivery. |
| format | Article |
| id | doaj-art-3bba64cbc8cd4576944ed0cd78e9554f |
| institution | Kabale University |
| issn | 2662-4443 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Materials |
| spelling | doaj-art-3bba64cbc8cd4576944ed0cd78e9554f2025-01-12T12:32:48ZengNature PortfolioCommunications Materials2662-44432025-01-016112210.1038/s43246-024-00721-yDevice-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastomaNassir Mokarram0Ayden Case1Nadia N. Hossainy2Johnathan G. Lyon3Tobey J. MacDonald4Ravi Bellamkonda5Department of Neurosurgery, Emory UniversityTrinity College of Arts and Sciences, Duke UniversityDepartment of Biology, Emory UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Pediatrics, Emory University School of MedicineDepartment of Biology, Emory UniversityAbstract The blood-brain barrier, essential for protecting the central nervous system, also restricts drug delivery to this region. Thus, delivering drugs across the blood-brain barrier is an active research area in immunology, oncology, and neurology; moreover, novel methods are urgently needed to expand therapeutic options for central nervous system pathologies. While previous strategies have focused on small molecules that modulate blood-brain barrier permeability or penetrate the barrier, there is an increased focus on biomedical devices—external or implanted—for improving drug delivery. Here, we review device-assisted drug delivery across the blood–brain barrier, emphasizing its application in glioblastoma, an aggressively malignant primary brain cancer in which the blood-brain barrier plays a central role. We examine the blood-brain barrier and its features in glioblastoma, emerging models for studying the blood-brain barrier, and device-assisted methods for crossing the blood-brain barrier. We conclude by presenting methods to monitor the blood-brain barrier and paradigms for combined cross-BBB drug delivery.https://doi.org/10.1038/s43246-024-00721-y |
| spellingShingle | Nassir Mokarram Ayden Case Nadia N. Hossainy Johnathan G. Lyon Tobey J. MacDonald Ravi Bellamkonda Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma Communications Materials |
| title | Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma |
| title_full | Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma |
| title_fullStr | Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma |
| title_full_unstemmed | Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma |
| title_short | Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma |
| title_sort | device assisted strategies for drug delivery across the blood brain barrier to treat glioblastoma |
| url | https://doi.org/10.1038/s43246-024-00721-y |
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