Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression
BackgroundDepression and suicidal behavior are associated with pro-inflammatory status in adults. However, differences in inflammatory levels among adolescents with depression at different suicide risk levels are unclear, and the connection between anti-inflammatory factors, which serve as vital for...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1491555/full |
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| author | Wenyuan Liu Wenyuan Liu Wenyuan Liu Wenyuan Liu Hongyu Zheng Hongyu Zheng Hongyu Zheng Xiaofei Wen Xiaofei Wen Xiaofei Wen Longxing Liu Longxing Liu Longxing Liu Longxing Liu Yue Yang Yue Yang Yue Yang Yue Yang Hui Zhong Hui Zhong Hui Zhong Hui Zhong |
| author_facet | Wenyuan Liu Wenyuan Liu Wenyuan Liu Wenyuan Liu Hongyu Zheng Hongyu Zheng Hongyu Zheng Xiaofei Wen Xiaofei Wen Xiaofei Wen Longxing Liu Longxing Liu Longxing Liu Longxing Liu Yue Yang Yue Yang Yue Yang Yue Yang Hui Zhong Hui Zhong Hui Zhong Hui Zhong |
| author_sort | Wenyuan Liu |
| collection | DOAJ |
| description | BackgroundDepression and suicidal behavior are associated with pro-inflammatory status in adults. However, differences in inflammatory levels among adolescents with depression at different suicide risk levels are unclear, and the connection between anti-inflammatory factors, which serve as vital for the immune system, and suicide needs to be explored.MethodsThis study recruited 111 adolescent patients with depression aged 13-18 and 23 healthy controls. Patients were divided into three subgroups according to suicidal ideation within the past week and history of suicide attempts. Severity of depression, suicidal ideation, and suicide risk were assessed using the Hamilton Depression Scale-17 (HAMD-17) and the Chinese version of the Beck Suicide Ideation Scale (BSI-CV). Plasma levels of IL-6, TNF-α, IFN-γ, IL-1β, and IL-10 in all participants were measured.ResultsPlasma levels of IL-6, TNF-α, IFN-γ, and IL-10 differed between the suicide risk subgroups, and the differences remained significant after controlling for severity of depressive symptoms using covariance analysis. Pairwise comparison indicated that plasma levels of these four cytokines in the high suicide risk group were higher than those in the low suicide risk group (all p<0.05), among which the level of IL-10 was significantly higher than that in the medium and low risk groups. IL-10 was positively correlated with the total score of the HAMD-17, BSI-CV, and suicidal ideation; the other four cytokines were also somewhat correlated with suicidal ideation (all p<0.05). IL-10 correlated positively with these four pro-inflammatory factors. Multiple linear regression analysis showed that IL-10 levels significant were associated with BSI-CV (β = 0.270, t = 2.897, p = 0.005) and HAMA-17 (β = 0.285, t = 3.041, p = 0.003) total scores. In binary logistic regression, after controlling for depressive symptoms, gender, age, BMI, and duration of illness: IL-10 level remained a risk factor for suicidal behavior (OR = 3.224, 95% CI 1.571-6.619 p = 0.001).ConclusionAdolescents with different suicide risk levels differed in plasma levels of pro-inflammatory factors and the anti-inflammatory factor IL-10. These differences were independent of depressive symptoms; high IL-10 levels may be a risk factor for suicidal behavior in depressed patients. Further research is needed to explore the relationship between anti-inflammatory factors and suicide. |
| format | Article |
| id | doaj-art-3bb57c8dbead4683a810295852b81720 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-3bb57c8dbead4683a810295852b817202025-01-15T06:10:41ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.14915551491555Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depressionWenyuan Liu0Wenyuan Liu1Wenyuan Liu2Wenyuan Liu3Hongyu Zheng4Hongyu Zheng5Hongyu Zheng6Xiaofei Wen7Xiaofei Wen8Xiaofei Wen9Longxing Liu10Longxing Liu11Longxing Liu12Longxing Liu13Yue Yang14Yue Yang15Yue Yang16Yue Yang17Hui Zhong18Hui Zhong19Hui Zhong20Hui Zhong21School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Anhui Mental Health Center, Hefei, ChinaDepartment of Child and Adolescents Psychology, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Hefei Fourth People’s Hospital, Anhui, ChinaDepartment of Child and Adolescents Psychology, Anhui Mental Health Center, Hefei, ChinaDepartment of Child and Adolescents Psychology, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Hefei Fourth People’s Hospital, Anhui, ChinaDepartment of Child and Adolescents Psychology, Anhui Mental Health Center, Hefei, ChinaDepartment of Child and Adolescents Psychology, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Hefei Fourth People’s Hospital, Anhui, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Anhui Mental Health Center, Hefei, ChinaDepartment of Child and Adolescents Psychology, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Hefei Fourth People’s Hospital, Anhui, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Anhui Mental Health Center, Hefei, ChinaDepartment of Child and Adolescents Psychology, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Hefei Fourth People’s Hospital, Anhui, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Anhui Mental Health Center, Hefei, ChinaDepartment of Child and Adolescents Psychology, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaDepartment of Child and Adolescents Psychology, Hefei Fourth People’s Hospital, Anhui, ChinaBackgroundDepression and suicidal behavior are associated with pro-inflammatory status in adults. However, differences in inflammatory levels among adolescents with depression at different suicide risk levels are unclear, and the connection between anti-inflammatory factors, which serve as vital for the immune system, and suicide needs to be explored.MethodsThis study recruited 111 adolescent patients with depression aged 13-18 and 23 healthy controls. Patients were divided into three subgroups according to suicidal ideation within the past week and history of suicide attempts. Severity of depression, suicidal ideation, and suicide risk were assessed using the Hamilton Depression Scale-17 (HAMD-17) and the Chinese version of the Beck Suicide Ideation Scale (BSI-CV). Plasma levels of IL-6, TNF-α, IFN-γ, IL-1β, and IL-10 in all participants were measured.ResultsPlasma levels of IL-6, TNF-α, IFN-γ, and IL-10 differed between the suicide risk subgroups, and the differences remained significant after controlling for severity of depressive symptoms using covariance analysis. Pairwise comparison indicated that plasma levels of these four cytokines in the high suicide risk group were higher than those in the low suicide risk group (all p<0.05), among which the level of IL-10 was significantly higher than that in the medium and low risk groups. IL-10 was positively correlated with the total score of the HAMD-17, BSI-CV, and suicidal ideation; the other four cytokines were also somewhat correlated with suicidal ideation (all p<0.05). IL-10 correlated positively with these four pro-inflammatory factors. Multiple linear regression analysis showed that IL-10 levels significant were associated with BSI-CV (β = 0.270, t = 2.897, p = 0.005) and HAMA-17 (β = 0.285, t = 3.041, p = 0.003) total scores. In binary logistic regression, after controlling for depressive symptoms, gender, age, BMI, and duration of illness: IL-10 level remained a risk factor for suicidal behavior (OR = 3.224, 95% CI 1.571-6.619 p = 0.001).ConclusionAdolescents with different suicide risk levels differed in plasma levels of pro-inflammatory factors and the anti-inflammatory factor IL-10. These differences were independent of depressive symptoms; high IL-10 levels may be a risk factor for suicidal behavior in depressed patients. Further research is needed to explore the relationship between anti-inflammatory factors and suicide.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1491555/fullsuicide riskdepressionadolescencepro-inflammatory stateanti-inflammatory factorsIL-10 |
| spellingShingle | Wenyuan Liu Wenyuan Liu Wenyuan Liu Wenyuan Liu Hongyu Zheng Hongyu Zheng Hongyu Zheng Xiaofei Wen Xiaofei Wen Xiaofei Wen Longxing Liu Longxing Liu Longxing Liu Longxing Liu Yue Yang Yue Yang Yue Yang Yue Yang Hui Zhong Hui Zhong Hui Zhong Hui Zhong Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression Frontiers in Psychiatry suicide risk depression adolescence pro-inflammatory state anti-inflammatory factors IL-10 |
| title | Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression |
| title_full | Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression |
| title_fullStr | Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression |
| title_full_unstemmed | Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression |
| title_short | Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression |
| title_sort | associations of pro inflammatory factors and il 10 levels with degree of suicide risk in adolescents with depression |
| topic | suicide risk depression adolescence pro-inflammatory state anti-inflammatory factors IL-10 |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1491555/full |
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