Worse survival of hepatocellular cancer patients with membranous insulin receptor overexpression

Worse survival of hepatocellular cancer patients with membranous insulin receptor overexpression

Abstract Hepatocellular cancer (HCC) therapy is in need for an ideal companion diagnostic. Preclinical experimental studies have identified the insulin receptor (IR) and its synergistic counterpart, the IGF1 receptor (IGF1R), as relevant in HCC development, and the ligands IGF1 and IGF2 have been fo...

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Main Authors: Steffen Markus Heckl, Carolin Schneider, Lukas Kercher, Hans-Michael Behrens, Jan-Paul Gundlach, Alexander Bernsmeier, Stephan Schmidt, Sandra Krüger, Felix Braun, Rainer Günther, Thomas Becker, Stefan Schreiber, Christoph Röcken
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Hepatocellular cancer
IGF1 receptor
Insulin receptor
Prognosis
Sorafenib
Online Access:https://doi.org/10.1038/s41598-025-85350-2
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