Comparison of matrix metalloproteinase levels in periodontal pockets treated with chlorhexidine and propolis
Natural antimicrobial products are attracting interest in the treatment of periodontal diseases due to their minimal or nonexistent side effects. Propolis, a complex resin content produced by bees, has drawn particular interest for its antibacterial effects, including inhibitory effects on periodont...
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International Journal of Secondary Metabolite
2024-11-01
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| Series: | International Journal of Secondary Metabolite |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/3870748 |
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| author | Ali Batuhan Bayırlı Fulden Cantaş Türkiş Ercan Saruhan İbrahim Kıvrak |
| author_facet | Ali Batuhan Bayırlı Fulden Cantaş Türkiş Ercan Saruhan İbrahim Kıvrak |
| author_sort | Ali Batuhan Bayırlı |
| collection | DOAJ |
| description | Natural antimicrobial products are attracting interest in the treatment of periodontal diseases due to their minimal or nonexistent side effects. Propolis, a complex resin content produced by bees, has drawn particular interest for its antibacterial effects, including inhibitory effects on periodontopathogenic bacterial species. This study compared the effects of propolis, a natural product, and chlorhexidine, the gold standard antimicrobial agent, on MMP-1 and MMP-9 levels in gingival crevicular fluid (GCF). Subgingival irrigations of chlorhexidine and propolis solutions were performed in selected deep periodontal pockets of periodontitis patients along with scaling and root planing. The treatment protocol was administered three times at one-month intervals starting from the initial day of the study. GCF MMP-1 and MMP-9 levels, along with clinical periodontal parameters, were evaluated before and after treatment. The study results showed that a statistically significant decrease in clinical periodontal parameters in both groups (p<0.001). Biochemical analysis revealed a statistically significant decrease in levels of GCF MMP-1 and MMP-9 in both groups (p<0.005). Additionally, the decrease in GCF MMP-1 levels was found to be significantly greater in the propolis group compared to the chlorhexidine group (p<0.001). |
| format | Article |
| id | doaj-art-3b9e4210c8af4ecfb4d679079f2136a7 |
| institution | Kabale University |
| issn | 2148-6905 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | International Journal of Secondary Metabolite |
| record_format | Article |
| series | International Journal of Secondary Metabolite |
| spelling | doaj-art-3b9e4210c8af4ecfb4d679079f2136a72024-12-06T09:58:39ZengInternational Journal of Secondary MetaboliteInternational Journal of Secondary Metabolite2148-69052024-11-0111472973910.21448/ijsm.1470256618Comparison of matrix metalloproteinase levels in periodontal pockets treated with chlorhexidine and propolisAli Batuhan Bayırlı0https://orcid.org/0000-0003-1028-9461Fulden Cantaş Türkiş1https://orcid.org/0000-0002-7018-7187Ercan Saruhan2https://orcid.org/0000-0001-6416-1442İbrahim Kıvrak3https://orcid.org/0000-0001-9718-8238MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİMUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, TIP FAKÜLTESİMUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, TIP FAKÜLTESİMUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, MUĞLA MESLEK YÜKSEKOKULUNatural antimicrobial products are attracting interest in the treatment of periodontal diseases due to their minimal or nonexistent side effects. Propolis, a complex resin content produced by bees, has drawn particular interest for its antibacterial effects, including inhibitory effects on periodontopathogenic bacterial species. This study compared the effects of propolis, a natural product, and chlorhexidine, the gold standard antimicrobial agent, on MMP-1 and MMP-9 levels in gingival crevicular fluid (GCF). Subgingival irrigations of chlorhexidine and propolis solutions were performed in selected deep periodontal pockets of periodontitis patients along with scaling and root planing. The treatment protocol was administered three times at one-month intervals starting from the initial day of the study. GCF MMP-1 and MMP-9 levels, along with clinical periodontal parameters, were evaluated before and after treatment. The study results showed that a statistically significant decrease in clinical periodontal parameters in both groups (p<0.001). Biochemical analysis revealed a statistically significant decrease in levels of GCF MMP-1 and MMP-9 in both groups (p<0.005). Additionally, the decrease in GCF MMP-1 levels was found to be significantly greater in the propolis group compared to the chlorhexidine group (p<0.001).https://dergipark.org.tr/en/download/article-file/3870748chlorhexidinepropolissubgingival irrigationmmp-1mmp-9chlorhexidinepropolissubgingival irrigationmmp-1mmp-9 |
| spellingShingle | Ali Batuhan Bayırlı Fulden Cantaş Türkiş Ercan Saruhan İbrahim Kıvrak Comparison of matrix metalloproteinase levels in periodontal pockets treated with chlorhexidine and propolis International Journal of Secondary Metabolite chlorhexidine propolis subgingival irrigation mmp-1 mmp-9 chlorhexidine propolis subgingival irrigation mmp-1 mmp-9 |
| title | Comparison of matrix metalloproteinase levels in periodontal pockets treated with chlorhexidine and propolis |
| title_full | Comparison of matrix metalloproteinase levels in periodontal pockets treated with chlorhexidine and propolis |
| title_fullStr | Comparison of matrix metalloproteinase levels in periodontal pockets treated with chlorhexidine and propolis |
| title_full_unstemmed | Comparison of matrix metalloproteinase levels in periodontal pockets treated with chlorhexidine and propolis |
| title_short | Comparison of matrix metalloproteinase levels in periodontal pockets treated with chlorhexidine and propolis |
| title_sort | comparison of matrix metalloproteinase levels in periodontal pockets treated with chlorhexidine and propolis |
| topic | chlorhexidine propolis subgingival irrigation mmp-1 mmp-9 chlorhexidine propolis subgingival irrigation mmp-1 mmp-9 |
| url | https://dergipark.org.tr/en/download/article-file/3870748 |
| work_keys_str_mv | AT alibatuhanbayırlı comparisonofmatrixmetalloproteinaselevelsinperiodontalpocketstreatedwithchlorhexidineandpropolis AT fuldencantasturkis comparisonofmatrixmetalloproteinaselevelsinperiodontalpocketstreatedwithchlorhexidineandpropolis AT ercansaruhan comparisonofmatrixmetalloproteinaselevelsinperiodontalpocketstreatedwithchlorhexidineandpropolis AT ibrahimkıvrak comparisonofmatrixmetalloproteinaselevelsinperiodontalpocketstreatedwithchlorhexidineandpropolis |