Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies
The olfactory bulb (OB) shows early neuropathological hallmarks in numerous neurodegenerative diseases, for example, in Alzheimer’s disease (AD) and Parkinson’s disease (PD). The glomerular and granular cell layer of the OB is characterized by preserved cellular plasticity in the adult brain. In tur...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/3851262 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849304621765361664 |
|---|---|
| author | Zacharias Kohl Johannes C. M. Schlachetzki Judith Feldewerth Philipp Hornauer Martina Münch Anthony Adame Markus J. Riemenschneider Jürgen Winkler Eliezer Masliah |
| author_facet | Zacharias Kohl Johannes C. M. Schlachetzki Judith Feldewerth Philipp Hornauer Martina Münch Anthony Adame Markus J. Riemenschneider Jürgen Winkler Eliezer Masliah |
| author_sort | Zacharias Kohl |
| collection | DOAJ |
| description | The olfactory bulb (OB) shows early neuropathological hallmarks in numerous neurodegenerative diseases, for example, in Alzheimer’s disease (AD) and Parkinson’s disease (PD). The glomerular and granular cell layer of the OB is characterized by preserved cellular plasticity in the adult brain. In turn, alterations of this cellular plasticity are related to neuroinflammation such as microglia activation, implicated in the pathogenesis of AD and PD, as well as frontotemporal lobe degeneration (FTLD). To determine microglia proliferation and activation we analyzed ionized calcium binding adaptor molecule 1 (Iba1) expressing microglia in the glomerular and granular cell layer, and the olfactory tract of the OB from patients with AD, PD dementia/dementia with Lewy bodies (PDD/DLB), and FTLD compared to age-matched controls. The number of Iba1 and CD68 positive microglia associated with enlarged amoeboid microglia was increased particularly in AD, to a lesser extent in FTLD and PDD/DLB as well, while the proportion of proliferating microglia was not altered. In addition, cells expressing the immature neuronal marker polysialylated neural cell adhesion molecule (PSA-NCAM) were increased in the glomerular layer of PDD/DLB and FTLD cases only. These findings provide novel and detailed insights into differential levels of microglia activation in the OB of neurodegenerative diseases. |
| format | Article |
| id | doaj-art-3b97e42c520a4a27a43cef33023dd092 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3b97e42c520a4a27a43cef33023dd0922025-08-20T03:55:41ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/38512623851262Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative ProteinopathiesZacharias Kohl0Johannes C. M. Schlachetzki1Judith Feldewerth2Philipp Hornauer3Martina Münch4Anthony Adame5Markus J. Riemenschneider6Jürgen Winkler7Eliezer Masliah8Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, GermanyDepartment of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, GermanyDepartment of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, GermanyDepartment of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, GermanyDepartment of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, GermanyDepartments of Neurosciences and Pathology, University of California, La Jolla, San Diego, CA, USADepartment of Neuropathology, Regensburg University Hospital, 93053 Regensburg, GermanyDepartment of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, GermanyDepartments of Neurosciences and Pathology, University of California, La Jolla, San Diego, CA, USAThe olfactory bulb (OB) shows early neuropathological hallmarks in numerous neurodegenerative diseases, for example, in Alzheimer’s disease (AD) and Parkinson’s disease (PD). The glomerular and granular cell layer of the OB is characterized by preserved cellular plasticity in the adult brain. In turn, alterations of this cellular plasticity are related to neuroinflammation such as microglia activation, implicated in the pathogenesis of AD and PD, as well as frontotemporal lobe degeneration (FTLD). To determine microglia proliferation and activation we analyzed ionized calcium binding adaptor molecule 1 (Iba1) expressing microglia in the glomerular and granular cell layer, and the olfactory tract of the OB from patients with AD, PD dementia/dementia with Lewy bodies (PDD/DLB), and FTLD compared to age-matched controls. The number of Iba1 and CD68 positive microglia associated with enlarged amoeboid microglia was increased particularly in AD, to a lesser extent in FTLD and PDD/DLB as well, while the proportion of proliferating microglia was not altered. In addition, cells expressing the immature neuronal marker polysialylated neural cell adhesion molecule (PSA-NCAM) were increased in the glomerular layer of PDD/DLB and FTLD cases only. These findings provide novel and detailed insights into differential levels of microglia activation in the OB of neurodegenerative diseases.http://dx.doi.org/10.1155/2017/3851262 |
| spellingShingle | Zacharias Kohl Johannes C. M. Schlachetzki Judith Feldewerth Philipp Hornauer Martina Münch Anthony Adame Markus J. Riemenschneider Jürgen Winkler Eliezer Masliah Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies Neural Plasticity |
| title | Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies |
| title_full | Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies |
| title_fullStr | Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies |
| title_full_unstemmed | Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies |
| title_short | Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies |
| title_sort | distinct pattern of microgliosis in the olfactory bulb of neurodegenerative proteinopathies |
| url | http://dx.doi.org/10.1155/2017/3851262 |
| work_keys_str_mv | AT zachariaskohl distinctpatternofmicrogliosisintheolfactorybulbofneurodegenerativeproteinopathies AT johannescmschlachetzki distinctpatternofmicrogliosisintheolfactorybulbofneurodegenerativeproteinopathies AT judithfeldewerth distinctpatternofmicrogliosisintheolfactorybulbofneurodegenerativeproteinopathies AT philipphornauer distinctpatternofmicrogliosisintheolfactorybulbofneurodegenerativeproteinopathies AT martinamunch distinctpatternofmicrogliosisintheolfactorybulbofneurodegenerativeproteinopathies AT anthonyadame distinctpatternofmicrogliosisintheolfactorybulbofneurodegenerativeproteinopathies AT markusjriemenschneider distinctpatternofmicrogliosisintheolfactorybulbofneurodegenerativeproteinopathies AT jurgenwinkler distinctpatternofmicrogliosisintheolfactorybulbofneurodegenerativeproteinopathies AT eliezermasliah distinctpatternofmicrogliosisintheolfactorybulbofneurodegenerativeproteinopathies |