Immune response to influenza A(H1N1)v in HIV-infected patients
Introduction: HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking. Methodology: Data from seven HIV-positive and 14 HIV-negative patients infected with A...
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The Journal of Infection in Developing Countries
2014-01-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/3147 |
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| author | Paola Sansonetti Michela Sali Massimiliano Fabbiani Matteo Morandi Rosa Martucci Ali Danesh Giovanni Delogu Jesus Bermejo-Martin Maurizio Sanguinetti David Kelvin Roberto Cauda Giovanni Fadda Salvatore Rubino |
| author_facet | Paola Sansonetti Michela Sali Massimiliano Fabbiani Matteo Morandi Rosa Martucci Ali Danesh Giovanni Delogu Jesus Bermejo-Martin Maurizio Sanguinetti David Kelvin Roberto Cauda Giovanni Fadda Salvatore Rubino |
| author_sort | Paola Sansonetti |
| collection | DOAJ |
| description | Introduction: HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking.
Methodology: Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus.
Results: Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups.
Conclusions: The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture.
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| format | Article |
| id | doaj-art-3b89f09f1a0045289fef7f75ad511c82 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-3b89f09f1a0045289fef7f75ad511c822025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802014-01-0180110.3855/jidc.3147Immune response to influenza A(H1N1)v in HIV-infected patientsPaola Sansonetti0Michela Sali1Massimiliano Fabbiani2Matteo Morandi3Rosa Martucci4Ali Danesh5Giovanni Delogu6Jesus Bermejo-Martin7Maurizio Sanguinetti8David Kelvin9Roberto Cauda10Giovanni Fadda11Salvatore Rubino12Catholic University of Sacred Heart, Rome, ItalyCatholic University of Sacred Heart, Rome, ItalyCatholic University of Sacred Heart, Rome, ItalyCatholic University of Sacred Heart, Rome, ItalyCatholic University of Sacred Heart, Rome, ItalyInternational Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, ChinaCatholic University of Sacred Heart, Rome, ItalyInfection and Immunity Medical Investigation Unit (IMI), Microbiology and Immunology Service, Hospital Clínico Universitario-IECSCYL, Valladolid, SpainCatholic University of Sacred Heart, Rome, ItalyInternational Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, ChinaCatholic University of Sacred Heart, Rome, ItalyCatholic University of Sacred Heart, Rome, ItalyUniversity of Sassari, Sassari, ItalyIntroduction: HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking. Methodology: Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus. Results: Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups. Conclusions: The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture. https://jidc.org/index.php/journal/article/view/3147HIVinfluenza A(H1N1)v 2009cytokineschemokinesantibody response |
| spellingShingle | Paola Sansonetti Michela Sali Massimiliano Fabbiani Matteo Morandi Rosa Martucci Ali Danesh Giovanni Delogu Jesus Bermejo-Martin Maurizio Sanguinetti David Kelvin Roberto Cauda Giovanni Fadda Salvatore Rubino Immune response to influenza A(H1N1)v in HIV-infected patients Journal of Infection in Developing Countries HIV influenza A(H1N1)v 2009 cytokines chemokines antibody response |
| title | Immune response to influenza A(H1N1)v in HIV-infected patients |
| title_full | Immune response to influenza A(H1N1)v in HIV-infected patients |
| title_fullStr | Immune response to influenza A(H1N1)v in HIV-infected patients |
| title_full_unstemmed | Immune response to influenza A(H1N1)v in HIV-infected patients |
| title_short | Immune response to influenza A(H1N1)v in HIV-infected patients |
| title_sort | immune response to influenza a h1n1 v in hiv infected patients |
| topic | HIV influenza A(H1N1)v 2009 cytokines chemokines antibody response |
| url | https://jidc.org/index.php/journal/article/view/3147 |
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