Retrospective epidemiological analysis of pulmonary tuberculosis in the older adult and characterization of rifampicin resistance-associated rpoB mutations in Nantong City, China (2014–2023)
ObjectiveTo analyze the prevalence trend of older adult pulmonary tuberculosis (ETB) and the distribution and outcome of rifampicin-resistant rpoB gene mutation in ETB patients in Nantong.MethodsThe pulmonary tuberculosis patients’ data in Nantong from 2014 to 2023 were from Tuberculosis Information...
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Frontiers Media S.A.
2025-05-01
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| author | Huiming Zhu Shouwei Wang Xiaofang Zhao Peipei Wu Ji Chen Feng Li |
| author_facet | Huiming Zhu Shouwei Wang Xiaofang Zhao Peipei Wu Ji Chen Feng Li |
| author_sort | Huiming Zhu |
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| description | ObjectiveTo analyze the prevalence trend of older adult pulmonary tuberculosis (ETB) and the distribution and outcome of rifampicin-resistant rpoB gene mutation in ETB patients in Nantong.MethodsThe pulmonary tuberculosis patients’ data in Nantong from 2014 to 2023 were from Tuberculosis Information Management Syste and ETB and rifampicin-resistant rpoB mutation patients were retrospectively analyzed.ResultsFrom 2014 to 2023, the overall standardized incidence of ETB in Nantong showed a trend of rapid decline and tended to a stable trend stabilized. A total of 140 older adult patients with rifampin resistance, aged 60–69 years, 87 cases (62.1%). single-gene mutation Probe E mutations were the most frequent, observed in 39 cases (60.0%). Specifically, 52 cases (80.00%) were resistant to rifampicin, and Probe E of 31 cases (59.62%) showed the most mutations. The outcome of ETB patients with rifampicin resistance were significantly correlated with treatment classification, rifampicin resistance, Xpert MTB first test, and 0-month sequential sputum positivity.ConclusionThe number of ETB in Nantong from 2014 to 2023 showed a rapid decline and stabilized. The rpoB mutations in the ETB rifampicin-resistant patients were mainly single-gene mutations. The authorities should formulate effective regional prevention and control measures based on the characteristics of the ETB rifampicin-resistant patients. |
| format | Article |
| id | doaj-art-3b58c8328fe44e6dbec5c46ab8570f3d |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-3b58c8328fe44e6dbec5c46ab8570f3d2025-08-20T03:48:23ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-05-011310.3389/fpubh.2025.15772111577211Retrospective epidemiological analysis of pulmonary tuberculosis in the older adult and characterization of rifampicin resistance-associated rpoB mutations in Nantong City, China (2014–2023)Huiming Zhu0Shouwei Wang1Xiaofang Zhao2Peipei Wu3Ji Chen4Feng Li5Department of Clinical Laboratory, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, ChinaDepartment of Clinical Laboratory, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, ChinaDepartment of Public Health, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, ChinaQinzao Health Service Center of Nantong, Nantong, ChinaDepartment of Chronic Infectious Diseases, Nantong Center for Disease Control and Prevention, Nantong, ChinaDepartment of Clinical Laboratory, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, ChinaObjectiveTo analyze the prevalence trend of older adult pulmonary tuberculosis (ETB) and the distribution and outcome of rifampicin-resistant rpoB gene mutation in ETB patients in Nantong.MethodsThe pulmonary tuberculosis patients’ data in Nantong from 2014 to 2023 were from Tuberculosis Information Management Syste and ETB and rifampicin-resistant rpoB mutation patients were retrospectively analyzed.ResultsFrom 2014 to 2023, the overall standardized incidence of ETB in Nantong showed a trend of rapid decline and tended to a stable trend stabilized. A total of 140 older adult patients with rifampin resistance, aged 60–69 years, 87 cases (62.1%). single-gene mutation Probe E mutations were the most frequent, observed in 39 cases (60.0%). Specifically, 52 cases (80.00%) were resistant to rifampicin, and Probe E of 31 cases (59.62%) showed the most mutations. The outcome of ETB patients with rifampicin resistance were significantly correlated with treatment classification, rifampicin resistance, Xpert MTB first test, and 0-month sequential sputum positivity.ConclusionThe number of ETB in Nantong from 2014 to 2023 showed a rapid decline and stabilized. The rpoB mutations in the ETB rifampicin-resistant patients were mainly single-gene mutations. The authorities should formulate effective regional prevention and control measures based on the characteristics of the ETB rifampicin-resistant patients.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1577211/fullMycobacterium tuberculosisolder adult pulmonary tuberculosisrifampicin resistancerpoB gene mutationretrospective analysis |
| spellingShingle | Huiming Zhu Shouwei Wang Xiaofang Zhao Peipei Wu Ji Chen Feng Li Retrospective epidemiological analysis of pulmonary tuberculosis in the older adult and characterization of rifampicin resistance-associated rpoB mutations in Nantong City, China (2014–2023) Frontiers in Public Health Mycobacterium tuberculosis older adult pulmonary tuberculosis rifampicin resistance rpoB gene mutation retrospective analysis |
| title | Retrospective epidemiological analysis of pulmonary tuberculosis in the older adult and characterization of rifampicin resistance-associated rpoB mutations in Nantong City, China (2014–2023) |
| title_full | Retrospective epidemiological analysis of pulmonary tuberculosis in the older adult and characterization of rifampicin resistance-associated rpoB mutations in Nantong City, China (2014–2023) |
| title_fullStr | Retrospective epidemiological analysis of pulmonary tuberculosis in the older adult and characterization of rifampicin resistance-associated rpoB mutations in Nantong City, China (2014–2023) |
| title_full_unstemmed | Retrospective epidemiological analysis of pulmonary tuberculosis in the older adult and characterization of rifampicin resistance-associated rpoB mutations in Nantong City, China (2014–2023) |
| title_short | Retrospective epidemiological analysis of pulmonary tuberculosis in the older adult and characterization of rifampicin resistance-associated rpoB mutations in Nantong City, China (2014–2023) |
| title_sort | retrospective epidemiological analysis of pulmonary tuberculosis in the older adult and characterization of rifampicin resistance associated rpob mutations in nantong city china 2014 2023 |
| topic | Mycobacterium tuberculosis older adult pulmonary tuberculosis rifampicin resistance rpoB gene mutation retrospective analysis |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1577211/full |
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