A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers

A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers

Abstract Background Group A streptococci (Strep A) orStreptococcus pyogenes is a major human pathogen causing an estimated 500,000 deaths worldwide each year. Disease can range from mild pharyngitis to more severe infections, such as necrotizing fasciitis, septicemia, and toxic shock syndrome. Untre...

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Main Authors: Vanessa Meier-Stephenson, Michael T. Hawkes, Catherine Burton, Ainslie Calcutt, Chris Davis, Jessica Dooley, Michael Good, Michael Houghton, Eloise Keeffe, Kelly Kim, Ailin Lepletier, Conar O’Neil, Ijeoma Ogbuehi, Victoria Ozberk, Manisha Pandey, Simone Reynolds, Avi Seth, William Stokes, Alena Tse-Chang, Ben Tyrrell, D. Lorne Tyrrell, Gregory J. Tyrrell, Maryna Yaskina
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Trials
Subjects:
Group A streptococcus (GAS; Strep a)
Phase I vaccine clinical trial
M protein
Spy-CEP
Streptococcus pyogenes
Online Access:https://doi.org/10.1186/s13063-024-08634-4
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https://doi.org/10.1186/s13063-024-08634-4

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