Mammalian adaptation risk in HPAI H5N8: a comprehensive model bridging experimental data with mathematical insights

Mammalian adaptation risk in HPAI H5N8: a comprehensive model bridging experimental data with mathematical insights

Understanding the mammalian pathogenesis and interspecies transmission of HPAI H5N8 virus hinges on mapping its adaptive markers. We used deep sequencing to track these markers over five passages in murine lung tissue. Subsequently, we evaluated the growth, selection, and RNA load of eight recombina...

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Bibliographic Details
Main Authors: Santosh Chokkakula, Sol Oh, Won-Suk Choi, Chang Il Kim, Ju Hwan Jeong, Beom Kyu Kim, Ji-Hyun Park, Seong Cheol Min, Eung-Gook Kim, Yun Hee Baek, Young Ki Choi, Min-Suk Song
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
HPAI H5N8
replication
adaptation
RNA load
regression
quantification
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2339949
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