Potential of Deer Placenta Extract in Hair Cell Regeneration and Its Nanoniosome-Microspicule Gel as a Transfollicular Delivery System
Background: Deer placenta extract (DPE), rich in bioactive macromolecules, promotes regenerative effects in both normal and damaged cells. However, effective delivery of these macromolecules through the skin remains a challenge. Objectives: To investigate the potential of DPE in regenerating hair ce...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Cosmetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9284/11/6/204 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846105126677250048 |
|---|---|
| author | Worranan Rangsimawong Sureewan Duangjit Phaijit Sritananuwat Tanasait Ngawhirunpat Praneet Opanasopit |
| author_facet | Worranan Rangsimawong Sureewan Duangjit Phaijit Sritananuwat Tanasait Ngawhirunpat Praneet Opanasopit |
| author_sort | Worranan Rangsimawong |
| collection | DOAJ |
| description | Background: Deer placenta extract (DPE), rich in bioactive macromolecules, promotes regenerative effects in both normal and damaged cells. However, effective delivery of these macromolecules through the skin remains a challenge. Objectives: To investigate the potential of DPE in regenerating hair cells and to develop a nanoniosome (NS) and microspicule (MS) formulation as a promising transfollicular delivery system. Methods: The bioactivity of DPE was assessed in human follicle dermal papilla (HFDP) cells, including cells damaged by chemotherapy. The NS-MS formulation was designed to deliver biomacromolecules from DPE into skin and hair follicles. Results: DPE at 2000 µg/mL exhibited no cytotoxicity and significantly enhanced proliferation in both normal and cisplatin-treated HFDP cells. The DPE-loaded NSs displayed nanovesicles with a uniform size distribution and a negative surface charge. When incorporated into the MS gel, NS-MS demonstrated a synergistic effect, significantly enhancing the transdermal and transfollicular delivery of macromolecular protein into the skin layers and hair follicles. Conclusions: DPE promoted hair cell proliferation and facilitated the recovery of hair cells damaged by chemotherapy, especially when formulated into the NS-MS system, which effectively delivered bioactive macromolecules to the target site. This suggests its potential role in promoting hair regrowth. |
| format | Article |
| id | doaj-art-3b406bf0de1f4df0b101c43002f2a543 |
| institution | Kabale University |
| issn | 2079-9284 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj-art-3b406bf0de1f4df0b101c43002f2a5432024-12-27T14:19:21ZengMDPI AGCosmetics2079-92842024-11-0111620410.3390/cosmetics11060204Potential of Deer Placenta Extract in Hair Cell Regeneration and Its Nanoniosome-Microspicule Gel as a Transfollicular Delivery SystemWorranan Rangsimawong0Sureewan Duangjit1Phaijit Sritananuwat2Tanasait Ngawhirunpat3Praneet Opanasopit4Innovation in Drug and Extract of Agriculture Research Group, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, ThailandInnovation in Drug and Extract of Agriculture Research Group, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, ThailandInnovation in Drug and Extract of Agriculture Research Group, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, ThailandDepartment of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandBackground: Deer placenta extract (DPE), rich in bioactive macromolecules, promotes regenerative effects in both normal and damaged cells. However, effective delivery of these macromolecules through the skin remains a challenge. Objectives: To investigate the potential of DPE in regenerating hair cells and to develop a nanoniosome (NS) and microspicule (MS) formulation as a promising transfollicular delivery system. Methods: The bioactivity of DPE was assessed in human follicle dermal papilla (HFDP) cells, including cells damaged by chemotherapy. The NS-MS formulation was designed to deliver biomacromolecules from DPE into skin and hair follicles. Results: DPE at 2000 µg/mL exhibited no cytotoxicity and significantly enhanced proliferation in both normal and cisplatin-treated HFDP cells. The DPE-loaded NSs displayed nanovesicles with a uniform size distribution and a negative surface charge. When incorporated into the MS gel, NS-MS demonstrated a synergistic effect, significantly enhancing the transdermal and transfollicular delivery of macromolecular protein into the skin layers and hair follicles. Conclusions: DPE promoted hair cell proliferation and facilitated the recovery of hair cells damaged by chemotherapy, especially when formulated into the NS-MS system, which effectively delivered bioactive macromolecules to the target site. This suggests its potential role in promoting hair regrowth.https://www.mdpi.com/2079-9284/11/6/204deer placenta extractbioactive macromoleculesdermal papilla cellschemotherapy-induced damage hair cellsniosomesmicrospicules |
| spellingShingle | Worranan Rangsimawong Sureewan Duangjit Phaijit Sritananuwat Tanasait Ngawhirunpat Praneet Opanasopit Potential of Deer Placenta Extract in Hair Cell Regeneration and Its Nanoniosome-Microspicule Gel as a Transfollicular Delivery System Cosmetics deer placenta extract bioactive macromolecules dermal papilla cells chemotherapy-induced damage hair cells niosomes microspicules |
| title | Potential of Deer Placenta Extract in Hair Cell Regeneration and Its Nanoniosome-Microspicule Gel as a Transfollicular Delivery System |
| title_full | Potential of Deer Placenta Extract in Hair Cell Regeneration and Its Nanoniosome-Microspicule Gel as a Transfollicular Delivery System |
| title_fullStr | Potential of Deer Placenta Extract in Hair Cell Regeneration and Its Nanoniosome-Microspicule Gel as a Transfollicular Delivery System |
| title_full_unstemmed | Potential of Deer Placenta Extract in Hair Cell Regeneration and Its Nanoniosome-Microspicule Gel as a Transfollicular Delivery System |
| title_short | Potential of Deer Placenta Extract in Hair Cell Regeneration and Its Nanoniosome-Microspicule Gel as a Transfollicular Delivery System |
| title_sort | potential of deer placenta extract in hair cell regeneration and its nanoniosome microspicule gel as a transfollicular delivery system |
| topic | deer placenta extract bioactive macromolecules dermal papilla cells chemotherapy-induced damage hair cells niosomes microspicules |
| url | https://www.mdpi.com/2079-9284/11/6/204 |
| work_keys_str_mv | AT worrananrangsimawong potentialofdeerplacentaextractinhaircellregenerationanditsnanoniosomemicrospiculegelasatransfolliculardeliverysystem AT sureewanduangjit potentialofdeerplacentaextractinhaircellregenerationanditsnanoniosomemicrospiculegelasatransfolliculardeliverysystem AT phaijitsritananuwat potentialofdeerplacentaextractinhaircellregenerationanditsnanoniosomemicrospiculegelasatransfolliculardeliverysystem AT tanasaitngawhirunpat potentialofdeerplacentaextractinhaircellregenerationanditsnanoniosomemicrospiculegelasatransfolliculardeliverysystem AT praneetopanasopit potentialofdeerplacentaextractinhaircellregenerationanditsnanoniosomemicrospiculegelasatransfolliculardeliverysystem |