Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes
Abstract This study presents a copper-catalyzed, substrate-controlled regio- and enantioselective intermolecular hydrosilylation method capable of accommodating a broad scope of alkenes and prochiral silanes. The approach offers an efficient and versatile pathway to generate enantioenriched linear a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55592-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559274382163968 |
|---|---|
| author | Xiao-Yan Zhu Wenyu Gao Jian-Lin Xu Zi-Lu Wang Jin-Bo Zhao Yun-He Xu |
| author_facet | Xiao-Yan Zhu Wenyu Gao Jian-Lin Xu Zi-Lu Wang Jin-Bo Zhao Yun-He Xu |
| author_sort | Xiao-Yan Zhu |
| collection | DOAJ |
| description | Abstract This study presents a copper-catalyzed, substrate-controlled regio- and enantioselective intermolecular hydrosilylation method capable of accommodating a broad scope of alkenes and prochiral silanes. The approach offers an efficient and versatile pathway to generate enantioenriched linear and branched alkyl-substituted Si-stereogenic silanes. Key features of this reaction include mild reaction conditions, simple catalytic systems, compatibility with diverse substrates, high yields and enantioselectivities. |
| format | Article |
| id | doaj-art-3b3a1fb7f40a45079515d70480069c2c |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-3b3a1fb7f40a45079515d70480069c2c2025-01-05T12:37:09ZengNature PortfolioNature Communications2041-17232025-01-0116111210.1038/s41467-024-55592-1Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral SilanesXiao-Yan Zhu0Wenyu Gao1Jian-Lin Xu2Zi-Lu Wang3Jin-Bo Zhao4Yun-He Xu5Department of Chemistry, University of Science and Technology of ChinaFaculty of Chemistry and Life Science, Changchun University of TechnologyDepartment of Chemistry, University of Science and Technology of ChinaDepartment of Chemistry, University of Science and Technology of ChinaFaculty of Chemistry and Life Science, Changchun University of TechnologyDepartment of Chemistry, University of Science and Technology of ChinaAbstract This study presents a copper-catalyzed, substrate-controlled regio- and enantioselective intermolecular hydrosilylation method capable of accommodating a broad scope of alkenes and prochiral silanes. The approach offers an efficient and versatile pathway to generate enantioenriched linear and branched alkyl-substituted Si-stereogenic silanes. Key features of this reaction include mild reaction conditions, simple catalytic systems, compatibility with diverse substrates, high yields and enantioselectivities.https://doi.org/10.1038/s41467-024-55592-1 |
| spellingShingle | Xiao-Yan Zhu Wenyu Gao Jian-Lin Xu Zi-Lu Wang Jin-Bo Zhao Yun-He Xu Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes Nature Communications |
| title | Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes |
| title_full | Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes |
| title_fullStr | Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes |
| title_full_unstemmed | Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes |
| title_short | Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes |
| title_sort | copper catalyzed intermolecular regio and enantioselective hydrosilylation of alkenes with prochiral silanes |
| url | https://doi.org/10.1038/s41467-024-55592-1 |
| work_keys_str_mv | AT xiaoyanzhu coppercatalyzedintermolecularregioandenantioselectivehydrosilylationofalkeneswithprochiralsilanes AT wenyugao coppercatalyzedintermolecularregioandenantioselectivehydrosilylationofalkeneswithprochiralsilanes AT jianlinxu coppercatalyzedintermolecularregioandenantioselectivehydrosilylationofalkeneswithprochiralsilanes AT ziluwang coppercatalyzedintermolecularregioandenantioselectivehydrosilylationofalkeneswithprochiralsilanes AT jinbozhao coppercatalyzedintermolecularregioandenantioselectivehydrosilylationofalkeneswithprochiralsilanes AT yunhexu coppercatalyzedintermolecularregioandenantioselectivehydrosilylationofalkeneswithprochiralsilanes |