Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-κB-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease
Conclusions: We first demonstrated that irisin alleviated cognitive impairment by inhibiting AhR/NF-κB-NLRP3-mediated pyroptosis of hippocampal neurons in CKD. Overall, irisin may have the potential to serve as a critical antipyroptotic agent for improving CKD-induced cognitive impairment.
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/2662362 |
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| _version_ | 1846116382431772672 |
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| author | Jialing Zhang Xingtong Dong Qi Pang Aihua Zhang |
| author_facet | Jialing Zhang Xingtong Dong Qi Pang Aihua Zhang |
| author_sort | Jialing Zhang |
| collection | DOAJ |
| description | Conclusions: We first demonstrated that irisin alleviated cognitive impairment by inhibiting AhR/NF-κB-NLRP3-mediated pyroptosis of hippocampal neurons in CKD. Overall, irisin may have the potential to serve as a critical antipyroptotic agent for improving CKD-induced cognitive impairment. |
| format | Article |
| id | doaj-art-3b2beb57aad44d4dba61b270af8d6704 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3b2beb57aad44d4dba61b270af8d67042024-12-19T00:00:04ZengWileyMediators of Inflammation1466-18612024-01-01202410.1155/mi/2662362Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-κB-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney DiseaseJialing Zhang0Xingtong Dong1Qi Pang2Aihua Zhang3Department of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyConclusions: We first demonstrated that irisin alleviated cognitive impairment by inhibiting AhR/NF-κB-NLRP3-mediated pyroptosis of hippocampal neurons in CKD. Overall, irisin may have the potential to serve as a critical antipyroptotic agent for improving CKD-induced cognitive impairment.http://dx.doi.org/10.1155/mi/2662362 |
| spellingShingle | Jialing Zhang Xingtong Dong Qi Pang Aihua Zhang Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-κB-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease Mediators of Inflammation |
| title | Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-κB-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease |
| title_full | Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-κB-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease |
| title_fullStr | Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-κB-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease |
| title_full_unstemmed | Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-κB-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease |
| title_short | Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-κB-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease |
| title_sort | irisin alleviates cognitive impairment by inhibiting ahr nf κb nlrp3 mediated pyroptosis of hippocampal neurons in chronic kidney disease |
| url | http://dx.doi.org/10.1155/mi/2662362 |
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