Collagen deposition in lung parenchyma driven by depletion of interstitial Lyve-1+ macrophages prevents cigarette smoke-induced emphysema and loss of airway function

Collagen deposition in lung parenchyma driven by depletion of interstitial Lyve-1+ macrophages prevents cigarette smoke-induced emphysema and loss of airway function

IntroductionCollagen is essential for maintaining lung structure and function and its remodeling has been associated with respiratory diseases including chronic obstructive pulmonary disease (COPD). However, the cellular mechanisms driving collagen remodeling and the functional implications of this...

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Main Authors: Yinebeb Mezgebu Dagnachew, Hwee Ying Lim, Liao Wupeng, Sheau Yng Lim, Sheng Jie Natalie Lim, Chung Hwee Thiam, Shu Wen Tan, Joan Lau Joo Eng, Dan Mei, Syaza Hazwany Mohammad Azhar, Wei Siong Ong, Qi Hui Caris Tan, Wai-Shiu Fred Wong, Veronique Angeli
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
macrophage
chronic obstructive pulmonary disease
collagen
extracellular matrice (ECM)
Lyve-1 macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1493395/full
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