Differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgia
We report the results of a long-term follow-up series in our center to verify the impact of biologically effective dose (BED) on the efficacy and safety of Gamma Knife radiosurgery (GKS) in the treatment of primary trigeminal neuralgia (TN). A total of 138 consecutive cases of primary TN receiving G...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1614981/full |
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| author | Hao Deng Yuan Gao Yuan Gao Yang Wu Mengqi Wang Linglong Xiao Runlin Chen Zhujun Zhang Wei Pan Wei Pan Wei Wang Wei Wang |
| author_facet | Hao Deng Yuan Gao Yuan Gao Yang Wu Mengqi Wang Linglong Xiao Runlin Chen Zhujun Zhang Wei Pan Wei Pan Wei Wang Wei Wang |
| author_sort | Hao Deng |
| collection | DOAJ |
| description | We report the results of a long-term follow-up series in our center to verify the impact of biologically effective dose (BED) on the efficacy and safety of Gamma Knife radiosurgery (GKS) in the treatment of primary trigeminal neuralgia (TN). A total of 138 consecutive cases of primary TN receiving GKS were included. A 4-mm collimator was used for all cases, and a median central dose of 85 Gy (range 70–90 Gy) was prescribed. The Barrow Neurological Institute Pain Scale was adopted to evaluate the severity of TN. The median follow-up period was 65.5 months (range 12–147 months). Overall, 123 (89.1%) patients eventually achieved effective relief. The influence of BED on treatment outcomes varied by target location. For patients with distal targets, BED was a significant predictor of treatment failure (OR: 0.996, 95% CI: 0.992–0.999, p = 0.02) and post-GKS complications (OR: 1.002, 95% CI: 1.000–1.004, p = 0.01). However, BED did not significantly influence outcomes in the proximal target subgroup, either for treatment failure or complications. No significant association was found between BED and long-term outcomes in the entire cohort or in any subgroup analysis. Adjusting GKS doses according to BED for the distal target may optimize clinical outcomes in TN patients. |
| format | Article |
| id | doaj-art-3b11e2f48a2746548db7c0e8369f3c5d |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-3b11e2f48a2746548db7c0e8369f3c5d2025-08-25T05:25:28ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-08-011610.3389/fneur.2025.16149811614981Differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgiaHao Deng0Yuan Gao1Yuan Gao2Yang Wu3Mengqi Wang4Linglong Xiao5Runlin Chen6Zhujun Zhang7Wei Pan8Wei Pan9Wei Wang10Wei Wang11Department of Neurosurgery, West China Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Chengdu, ChinaGamma Knife Center, West China Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Chengdu, ChinaGamma Knife Center, West China Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Chengdu, ChinaGamma Knife Center, West China Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Chengdu, ChinaGamma Knife Center, West China Hospital, Chengdu, ChinaWe report the results of a long-term follow-up series in our center to verify the impact of biologically effective dose (BED) on the efficacy and safety of Gamma Knife radiosurgery (GKS) in the treatment of primary trigeminal neuralgia (TN). A total of 138 consecutive cases of primary TN receiving GKS were included. A 4-mm collimator was used for all cases, and a median central dose of 85 Gy (range 70–90 Gy) was prescribed. The Barrow Neurological Institute Pain Scale was adopted to evaluate the severity of TN. The median follow-up period was 65.5 months (range 12–147 months). Overall, 123 (89.1%) patients eventually achieved effective relief. The influence of BED on treatment outcomes varied by target location. For patients with distal targets, BED was a significant predictor of treatment failure (OR: 0.996, 95% CI: 0.992–0.999, p = 0.02) and post-GKS complications (OR: 1.002, 95% CI: 1.000–1.004, p = 0.01). However, BED did not significantly influence outcomes in the proximal target subgroup, either for treatment failure or complications. No significant association was found between BED and long-term outcomes in the entire cohort or in any subgroup analysis. Adjusting GKS doses according to BED for the distal target may optimize clinical outcomes in TN patients.https://www.frontiersin.org/articles/10.3389/fneur.2025.1614981/fullbiologically effective dosegamma knife radiosurgeryprimary trigeminal neuralgiapain reliefrecurrence |
| spellingShingle | Hao Deng Yuan Gao Yuan Gao Yang Wu Mengqi Wang Linglong Xiao Runlin Chen Zhujun Zhang Wei Pan Wei Pan Wei Wang Wei Wang Differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgia Frontiers in Neurology biologically effective dose gamma knife radiosurgery primary trigeminal neuralgia pain relief recurrence |
| title | Differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgia |
| title_full | Differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgia |
| title_fullStr | Differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgia |
| title_full_unstemmed | Differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgia |
| title_short | Differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgia |
| title_sort | differential impact of biologically effective dose in distal versus proximal gamma knife targets for trigeminal neuralgia |
| topic | biologically effective dose gamma knife radiosurgery primary trigeminal neuralgia pain relief recurrence |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1614981/full |
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