Circulating Progranulin: A Promising Novel Diagnostic and Prognostic Biomarker in Canine Oncology
Progranulin (PGRN) is a pluripotent growth factor that has shown promise as a diagnostic and prognostic biomarker for various neoplastic conditions in humans. This study aims to explore the PGRN as a novel biomarker for diagnosing and predicting the prognosis in canine tumors. Dogs (<i>n</i...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/15/11/1605 |
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| Summary: | Progranulin (PGRN) is a pluripotent growth factor that has shown promise as a diagnostic and prognostic biomarker for various neoplastic conditions in humans. This study aims to explore the PGRN as a novel biomarker for diagnosing and predicting the prognosis in canine tumors. Dogs (<i>n</i> = 104) with tumors as the chief complaint were selected and classified based on clinical categorization, malignancy, and metastasis. The control group (<i>n</i> = 30) consisted of healthy dogs with no evidence of neoplastic diseases. Serum PGRN levels were quantified using enzyme-linked immunosorbent assay (ELISA). Dogs with tumors exhibited significantly elevated PGRN levels compared to control dogs (<i>p</i> < 0.0001), with a high sensitivity of 90.91%. Malignant tumors demonstrated markedly higher PGRN levels relative to the control group (<i>p</i> = 0.0012), while no significant difference was found between benign tumors and the control group. Additionally, serum PGRN was identified as a significant marker for differentiating metastatic tumors from non-metastatic ones (<i>p</i> = 0.0264). PGRN exhibited high sensitivity for tumor detection, suggesting that it may serve as a screening biomarker. Prognostically, increased PGRN correlated with unfavorable outcomes, notably linked to malignancy and metastasis. This study underscores the potential of PGRN as a novel biomarker with early diagnostic and prognostic value in canine oncology. |
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| ISSN: | 2076-2615 |