Real‐World Response and Survival Outcomes and Treatment Patterns in Patients With Extensive Stage Small‐Cell Lung Cancer Receiving Third‐Line Treatment
ABSTRACT Background Patients with small‐cell lung cancer (SCLC) primarily present with extensive stage (ES) disease and poor 5‐year survival. There are few treatment options and limited data on outcomes in third‐line (3L) ES SCLC to quantify unmet medical needs. This chart review evaluated real‐worl...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70289 |
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| author | Jair Bar Qingqing Xu Sudeep Karve Pooja Hingorani Amin A. Virani Neal E. Ready |
| author_facet | Jair Bar Qingqing Xu Sudeep Karve Pooja Hingorani Amin A. Virani Neal E. Ready |
| author_sort | Jair Bar |
| collection | DOAJ |
| description | ABSTRACT Background Patients with small‐cell lung cancer (SCLC) primarily present with extensive stage (ES) disease and poor 5‐year survival. There are few treatment options and limited data on outcomes in third‐line (3L) ES SCLC to quantify unmet medical needs. This chart review evaluated real‐world (RW) clinical outcomes and treatment patterns in these patients. Methods This retrospective study using electronic medical records included adult patients with ES SCLC (≥ 2 claims for metastasized lung cancer) who received ≥ 3 lines of therapy (LOT) at Cancer Treatment Centers of America (now City of Hope). Patients with other/multiple primary malignancies, non‐SCLC histology, or treated through a clinical trial were excluded. Clinical outcomes included RW physician‐reported response rates, duration of response (DOR), duration of clinical benefit (DoCB), overall survival (OS), and progression‐free survival (PFS), stratified by platinum sensitivity and Eastern Cooperative Oncology Group performance status (ECOG‐PS). Time‐to‐event outcomes were estimated via Kaplan–Meier. Treatment patterns were assessed, including the sequence of regimens by LOT and first‐line (1L) platinum sensitivity status. Results Among 113 eligible patients (median age 58 years), 54% were female, and 46% had a chemotherapy‐free interval after 1L of < 90 days. Tumor shrinkage, complete response, and stable disease were reported in 19%, 1%, and 13% of patients at 3L, respectively. The median DOR, DoCB, OS, and PFS were 2.8, 2.5, 5.8, and 2.4 months in 3L, respectively. Platinum‐resistant versus sensitive patients in 1L had shorter time‐to‐event outcomes. Clinical outcomes were similar regardless of ECOG‐PS status. Platinum‐based chemotherapy rates decreased from 94% and 93% in 1L to 17% and 16% in 3L in platinum‐sensitive and resistant patients, respectively. Conclusion These RW findings validate 3L results from clinical trials, demonstrating the limited clinical benefits with current therapies in 3L ES SCLC, and highlighting the urgent need for novel therapies that improve outcomes in this difficult‐to‐treat patient population. |
| format | Article |
| id | doaj-art-3b032db870024982b6e9e255933d381b |
| institution | Kabale University |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-3b032db870024982b6e9e255933d381b2025-08-26T06:00:41ZengWileyCancer Reports2573-83482025-08-0188n/an/a10.1002/cnr2.70289Real‐World Response and Survival Outcomes and Treatment Patterns in Patients With Extensive Stage Small‐Cell Lung Cancer Receiving Third‐Line TreatmentJair Bar0Qingqing Xu1Sudeep Karve2Pooja Hingorani3Amin A. Virani4Neal E. Ready5Jusidman Institute of Oncology, Sheba Medical Center Ramat Gan IsraelAbbVie Inc. North Chicago Illinois USAAbbVie Inc. North Chicago Illinois USAAbbVie Inc. North Chicago Illinois USAAbbVie Inc. North Chicago Illinois USADuke Cancer Institute, Duke University Durham North Carolina USAABSTRACT Background Patients with small‐cell lung cancer (SCLC) primarily present with extensive stage (ES) disease and poor 5‐year survival. There are few treatment options and limited data on outcomes in third‐line (3L) ES SCLC to quantify unmet medical needs. This chart review evaluated real‐world (RW) clinical outcomes and treatment patterns in these patients. Methods This retrospective study using electronic medical records included adult patients with ES SCLC (≥ 2 claims for metastasized lung cancer) who received ≥ 3 lines of therapy (LOT) at Cancer Treatment Centers of America (now City of Hope). Patients with other/multiple primary malignancies, non‐SCLC histology, or treated through a clinical trial were excluded. Clinical outcomes included RW physician‐reported response rates, duration of response (DOR), duration of clinical benefit (DoCB), overall survival (OS), and progression‐free survival (PFS), stratified by platinum sensitivity and Eastern Cooperative Oncology Group performance status (ECOG‐PS). Time‐to‐event outcomes were estimated via Kaplan–Meier. Treatment patterns were assessed, including the sequence of regimens by LOT and first‐line (1L) platinum sensitivity status. Results Among 113 eligible patients (median age 58 years), 54% were female, and 46% had a chemotherapy‐free interval after 1L of < 90 days. Tumor shrinkage, complete response, and stable disease were reported in 19%, 1%, and 13% of patients at 3L, respectively. The median DOR, DoCB, OS, and PFS were 2.8, 2.5, 5.8, and 2.4 months in 3L, respectively. Platinum‐resistant versus sensitive patients in 1L had shorter time‐to‐event outcomes. Clinical outcomes were similar regardless of ECOG‐PS status. Platinum‐based chemotherapy rates decreased from 94% and 93% in 1L to 17% and 16% in 3L in platinum‐sensitive and resistant patients, respectively. Conclusion These RW findings validate 3L results from clinical trials, demonstrating the limited clinical benefits with current therapies in 3L ES SCLC, and highlighting the urgent need for novel therapies that improve outcomes in this difficult‐to‐treat patient population.https://doi.org/10.1002/cnr2.70289clinical outcomesextensive stagereal‐worldSCLCthird‐linetreatment patterns |
| spellingShingle | Jair Bar Qingqing Xu Sudeep Karve Pooja Hingorani Amin A. Virani Neal E. Ready Real‐World Response and Survival Outcomes and Treatment Patterns in Patients With Extensive Stage Small‐Cell Lung Cancer Receiving Third‐Line Treatment Cancer Reports clinical outcomes extensive stage real‐world SCLC third‐line treatment patterns |
| title | Real‐World Response and Survival Outcomes and Treatment Patterns in Patients With Extensive Stage Small‐Cell Lung Cancer Receiving Third‐Line Treatment |
| title_full | Real‐World Response and Survival Outcomes and Treatment Patterns in Patients With Extensive Stage Small‐Cell Lung Cancer Receiving Third‐Line Treatment |
| title_fullStr | Real‐World Response and Survival Outcomes and Treatment Patterns in Patients With Extensive Stage Small‐Cell Lung Cancer Receiving Third‐Line Treatment |
| title_full_unstemmed | Real‐World Response and Survival Outcomes and Treatment Patterns in Patients With Extensive Stage Small‐Cell Lung Cancer Receiving Third‐Line Treatment |
| title_short | Real‐World Response and Survival Outcomes and Treatment Patterns in Patients With Extensive Stage Small‐Cell Lung Cancer Receiving Third‐Line Treatment |
| title_sort | real world response and survival outcomes and treatment patterns in patients with extensive stage small cell lung cancer receiving third line treatment |
| topic | clinical outcomes extensive stage real‐world SCLC third‐line treatment patterns |
| url | https://doi.org/10.1002/cnr2.70289 |
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