Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal study
Abstract Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) and is associated with peripheral inflammation. However, it is unclear whether such an enlargement delineates a biologically defined subgroup of SSD. Moreo...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-024-00543-4 |
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| author | Vladislav Yakimov Joanna Moussiopoulou Lukas Roell Marcel S. Kallweit Emanuel Boudriot Matin Mortazavi Sergi Papiol Lenka Krčmář Mattia Campana Eva C. Schulte Nicolas Glaichenhaus Emanuela Martinuzzi Sean Halstead Nicola Warren Dan Siskind Isabel Maurus Alkomiet Hasan Peter Falkai Andrea Schmitt Florian J. Raabe CDP Working Group Daniel Keeser Elias Wagner |
| author_facet | Vladislav Yakimov Joanna Moussiopoulou Lukas Roell Marcel S. Kallweit Emanuel Boudriot Matin Mortazavi Sergi Papiol Lenka Krčmář Mattia Campana Eva C. Schulte Nicolas Glaichenhaus Emanuela Martinuzzi Sean Halstead Nicola Warren Dan Siskind Isabel Maurus Alkomiet Hasan Peter Falkai Andrea Schmitt Florian J. Raabe CDP Working Group Daniel Keeser Elias Wagner |
| author_sort | Vladislav Yakimov |
| collection | DOAJ |
| description | Abstract Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) and is associated with peripheral inflammation. However, it is unclear whether such an enlargement delineates a biologically defined subgroup of SSD. Moreover, it remains elusive how ChP is linked to brain regions associated with peripheral inflammation in SSD. A cross-sectional cohort of 132 individuals with SSD and 107 age-matched healthy controls (HC) underwent cerebral magnetic resonance imaging (MRI) and clinical phenotyping to investigate the ChP and associated regions. A case-control comparison of ChP volumes was conducted, and structural variance was analyzed by employing the variability ratio (VR). K-means clustering analysis was used to identify subgroups with distinct patterns of the ventricular system, and the clusters were compared in terms of demographic, clinical, and immunological measures. The relationship between ChP volumes and brain regions, previously associated with peripheral inflammation, was investigated. We did not find a significant enlargement of the ChP in SSD compared to HC but detected an increased VR of ChP and lateral ventricle volumes. Based on these regions, we identified 3 clusters with differences in cognitive measures and possibly inflammatory markers. Larger ChP volume was associated with higher volumes of hippocampus, putamen, and thalamus in SSD but not in HC. This study suggests that ChP variability, but not mean volume, is increased in individuals with SSD, compared to HC. Larger ChP volumes in SSD were associated with higher volumes of regions previously associated with peripheral inflammation. |
| format | Article |
| id | doaj-art-3ae50e980fe445708d9039d0c98ffc74 |
| institution | Kabale University |
| issn | 2754-6993 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj-art-3ae50e980fe445708d9039d0c98ffc742024-12-22T12:32:07ZengNature PortfolioSchizophrenia2754-69932024-12-011011910.1038/s41537-024-00543-4Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal studyVladislav Yakimov0Joanna Moussiopoulou1Lukas Roell2Marcel S. Kallweit3Emanuel Boudriot4Matin Mortazavi5Sergi Papiol6Lenka Krčmář7Mattia Campana8Eva C. Schulte9Nicolas Glaichenhaus10Emanuela Martinuzzi11Sean Halstead12Nicola Warren13Dan Siskind14Isabel Maurus15Alkomiet Hasan16Peter Falkai17Andrea Schmitt18Florian J. Raabe19CDP Working GroupDaniel Keeser20Elias Wagner21Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichMax Planck Institute of PsychiatryDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichInstitute of Psychiatric Phenomics and Genomics, LMU University Hospital, LMU MunichInstitut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, Centre National de La Recherche ScientifiqueInstitut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, Centre National de La Recherche ScientifiqueMedical School, The University of QueenslandMedical School, The University of QueenslandMedical School, The University of QueenslandDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDZPG (German Center for Mental Health), partner site Munich/AugsburgDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU MunichAbstract Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) and is associated with peripheral inflammation. However, it is unclear whether such an enlargement delineates a biologically defined subgroup of SSD. Moreover, it remains elusive how ChP is linked to brain regions associated with peripheral inflammation in SSD. A cross-sectional cohort of 132 individuals with SSD and 107 age-matched healthy controls (HC) underwent cerebral magnetic resonance imaging (MRI) and clinical phenotyping to investigate the ChP and associated regions. A case-control comparison of ChP volumes was conducted, and structural variance was analyzed by employing the variability ratio (VR). K-means clustering analysis was used to identify subgroups with distinct patterns of the ventricular system, and the clusters were compared in terms of demographic, clinical, and immunological measures. The relationship between ChP volumes and brain regions, previously associated with peripheral inflammation, was investigated. We did not find a significant enlargement of the ChP in SSD compared to HC but detected an increased VR of ChP and lateral ventricle volumes. Based on these regions, we identified 3 clusters with differences in cognitive measures and possibly inflammatory markers. Larger ChP volume was associated with higher volumes of hippocampus, putamen, and thalamus in SSD but not in HC. This study suggests that ChP variability, but not mean volume, is increased in individuals with SSD, compared to HC. Larger ChP volumes in SSD were associated with higher volumes of regions previously associated with peripheral inflammation.https://doi.org/10.1038/s41537-024-00543-4 |
| spellingShingle | Vladislav Yakimov Joanna Moussiopoulou Lukas Roell Marcel S. Kallweit Emanuel Boudriot Matin Mortazavi Sergi Papiol Lenka Krčmář Mattia Campana Eva C. Schulte Nicolas Glaichenhaus Emanuela Martinuzzi Sean Halstead Nicola Warren Dan Siskind Isabel Maurus Alkomiet Hasan Peter Falkai Andrea Schmitt Florian J. Raabe CDP Working Group Daniel Keeser Elias Wagner Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal study Schizophrenia |
| title | Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal study |
| title_full | Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal study |
| title_fullStr | Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal study |
| title_full_unstemmed | Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal study |
| title_short | Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal study |
| title_sort | investigation of choroid plexus variability in schizophrenia spectrum disorders insights from a multimodal study |
| url | https://doi.org/10.1038/s41537-024-00543-4 |
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