The clinical and immunological profiles of systemic lupus erythematosus patients from Assam, North-East India
Objective: The objective of this study is to document the clinical and immunological profiles of systemic lupus erythematosus (SLE) patients from the Upper Assam region and to evaluate the relevance of autoantibody combinations on the clinical presentation of SLE. Materials and Methods: One hundred...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=3;spage=181;epage=186;aulast=Talukdar |
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| author | Debashree Talukdar Akash Protim Gogoi Daisy Doley Rebecca R Marak Sanjeeb Kakati Vandana Pradhan Anita H Nadkarni Shashi Baruah |
| author_facet | Debashree Talukdar Akash Protim Gogoi Daisy Doley Rebecca R Marak Sanjeeb Kakati Vandana Pradhan Anita H Nadkarni Shashi Baruah |
| author_sort | Debashree Talukdar |
| collection | DOAJ |
| description | Objective: The objective of this study is to document the clinical and immunological profiles of systemic lupus erythematosus (SLE) patients from the Upper Assam region and to evaluate the relevance of autoantibody combinations on the clinical presentation of SLE.
Materials and Methods: One hundred and forty-five SLE patients were enrolled in the study. Anti-nuclear antibody (ANA) profiles and titers of autoantibodies were determined using the ANA blot and enzyme-linked immunosorbent assay, respectively. The patients were clustered based on autoantibody titers and clinical features among the clusters were compared.
Results: Mucocutaneous (87.59%), hematological (69.65%), renal (58.03%), and musculoskeletal (50.34%) manifestations were the common clinical complications, whereas anti-double stranded deoxyribonucleic acid (dsDNA) antibody was noted in 62.76% of the patients. Patient clustering using autoantibody titers revealed that the cluster with a combination of high titers of anti-dsDNA, anti-nucleosome (Nuc), and anti-ribosomal P (Rib-P) antibody had complex disease presentation with higher frequencies of oral/nasal ulcer, serositis, musculoskeletal, hematological, and central nervous system manifestations.
Conclusion: The most common clinical features of the SLE patients were mucocutaneous, hematological, renal and musculoskeletal manifestations, and anti-dsDNA antibody was the most frequent autoantibody. A combination of high titers of anti-dsDNA, anti-Nuc, and anti-Rib-P antibodies showed association with disease complexity but not the combinations of autoantibodies against extractable nuclear antigens. |
| format | Article |
| id | doaj-art-3adb1a16b59b461b938bc52fbadec9bd |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-3adb1a16b59b461b938bc52fbadec9bd2025-01-03T01:45:46ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-0115318118610.4103/injr.injr_37_20The clinical and immunological profiles of systemic lupus erythematosus patients from Assam, North-East IndiaDebashree TalukdarAkash Protim GogoiDaisy DoleyRebecca R MarakSanjeeb KakatiVandana PradhanAnita H NadkarniShashi BaruahObjective: The objective of this study is to document the clinical and immunological profiles of systemic lupus erythematosus (SLE) patients from the Upper Assam region and to evaluate the relevance of autoantibody combinations on the clinical presentation of SLE. Materials and Methods: One hundred and forty-five SLE patients were enrolled in the study. Anti-nuclear antibody (ANA) profiles and titers of autoantibodies were determined using the ANA blot and enzyme-linked immunosorbent assay, respectively. The patients were clustered based on autoantibody titers and clinical features among the clusters were compared. Results: Mucocutaneous (87.59%), hematological (69.65%), renal (58.03%), and musculoskeletal (50.34%) manifestations were the common clinical complications, whereas anti-double stranded deoxyribonucleic acid (dsDNA) antibody was noted in 62.76% of the patients. Patient clustering using autoantibody titers revealed that the cluster with a combination of high titers of anti-dsDNA, anti-nucleosome (Nuc), and anti-ribosomal P (Rib-P) antibody had complex disease presentation with higher frequencies of oral/nasal ulcer, serositis, musculoskeletal, hematological, and central nervous system manifestations. Conclusion: The most common clinical features of the SLE patients were mucocutaneous, hematological, renal and musculoskeletal manifestations, and anti-dsDNA antibody was the most frequent autoantibody. A combination of high titers of anti-dsDNA, anti-Nuc, and anti-Rib-P antibodies showed association with disease complexity but not the combinations of autoantibodies against extractable nuclear antigens.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=3;spage=181;epage=186;aulast=Talukdarassamautoantibody profileautoantibody titernorth-east indiasystemic lupus erythematosus |
| spellingShingle | Debashree Talukdar Akash Protim Gogoi Daisy Doley Rebecca R Marak Sanjeeb Kakati Vandana Pradhan Anita H Nadkarni Shashi Baruah The clinical and immunological profiles of systemic lupus erythematosus patients from Assam, North-East India Indian Journal of Rheumatology assam autoantibody profile autoantibody titer north-east india systemic lupus erythematosus |
| title | The clinical and immunological profiles of systemic lupus erythematosus patients from Assam, North-East India |
| title_full | The clinical and immunological profiles of systemic lupus erythematosus patients from Assam, North-East India |
| title_fullStr | The clinical and immunological profiles of systemic lupus erythematosus patients from Assam, North-East India |
| title_full_unstemmed | The clinical and immunological profiles of systemic lupus erythematosus patients from Assam, North-East India |
| title_short | The clinical and immunological profiles of systemic lupus erythematosus patients from Assam, North-East India |
| title_sort | clinical and immunological profiles of systemic lupus erythematosus patients from assam north east india |
| topic | assam autoantibody profile autoantibody titer north-east india systemic lupus erythematosus |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=3;spage=181;epage=186;aulast=Talukdar |
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