FABP7 is increased in progressive multiple sclerosis and induces a pro-inflammatory phenotype in monocytes through a glycolytic switch

FABP7 is increased in progressive multiple sclerosis and induces a pro-inflammatory phenotype in monocytes through a glycolytic switch

Abstract Multiple sclerosis (MS) involves dysregulation of innate immune cells including monocytes, especially in progressive MS. Fatty acid binding proteins (FABP) are essential for fatty acid transport and metabolism in multiple cell types. FABP7, a brain-FABP, maintains metabolic function in astr...

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Main Authors: Rohit Patel, Devin King, Brenna LaBarre, Hrishikesh Lokhande, Danielle Caefer, Johnna F. Varghese, Keturah Warner, Marc A. Bouffard, Shrishti Saxena, Alena Zhirova, Rohit Bakshi, Tanuja Chitnis
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60747-9
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