Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents

Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents

Penicillin-binding proteins (PBPs) contribute to bacterial cell wall biosynthesis and are targets of antibacterial agents. Here, we investigated PBP1b inhibition by boronic acid derivatives. Chemical starting points were identified by structure-based virtual screening and aliphatic boronic acids wer...

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Bibliographic Details
Main Authors: Levente Kollár, Katarina Grabrijan, Martina Hrast Rambaher, Krištof Bozovičar, Tímea Imre, György G. Ferenczy, Stanislav Gobec, György M. Keserű
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Penicillin-binding proteins
covalent inhibitors
boronic acids
serine labelling
lysine labelling
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2305833
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