Disease Burden and Spectrum of Symptoms That Impact Quality of Life in Pediatric Patients With Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a progressive type 2 inflammatory disease characterized by symptoms related to esophageal dysfunction and significant esophageal eosinophilic infiltration. It can affect patients from infancy through adulthood. Pediatric EoE has a multidimensional impact on the qual...
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Elsevier
2024-01-01
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| Series: | Gastro Hep Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572324001249 |
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| author | Mirna Chehade Girish S. Hiremath Noam Zevit Salvatore Oliva Tiffany Pela Angela Khodzhayev Juby Jacob-Nara Amr Radwan |
| author_facet | Mirna Chehade Girish S. Hiremath Noam Zevit Salvatore Oliva Tiffany Pela Angela Khodzhayev Juby Jacob-Nara Amr Radwan |
| author_sort | Mirna Chehade |
| collection | DOAJ |
| description | Eosinophilic esophagitis (EoE) is a progressive type 2 inflammatory disease characterized by symptoms related to esophageal dysfunction and significant esophageal eosinophilic infiltration. It can affect patients from infancy through adulthood. Pediatric EoE has a multidimensional impact on the quality of life of both patients and their families. Nonspecific symptoms mimicking other gastrointestinal conditions, such as food refusal, failure to thrive, and feeding difficulties, may profoundly affect young children’s eating skills, growth, and psychosocial status, as well as impact family financial conditions. In adolescence, dysphagia and esophageal food impactions often lead to feeding-related anxiety and influence social lives. Delays in diagnosis, arising from lack of awareness among families and clinicians and compensatory eating behaviors, could increase the risk of fibrostenotic complications, which may ultimately add to the symptom burden. Currently available treatment options include proton pump inhibitors, dietary therapies, swallowed topical steroids, esophageal dilation, and biologic therapy. Despite the efficacy of these approaches, disease burden may be further impacted by their limitations, including poor adherence rates, refractory disease, potential long-term safety concerns, and high costs for care. Thus, there is a need for more timely diagnosis in clinical practice and novel targeted disease-modifying therapies better tailored to treat various phenotypes of EoE, aimed at reducing the physical and psychosocial burdens on patients and their caregivers. |
| format | Article |
| id | doaj-art-3a70557f3c70498caddee7d9d396a24d |
| institution | Kabale University |
| issn | 2772-5723 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj-art-3a70557f3c70498caddee7d9d396a24d2024-11-29T06:26:27ZengElsevierGastro Hep Advances2772-57232024-01-013810541068Disease Burden and Spectrum of Symptoms That Impact Quality of Life in Pediatric Patients With Eosinophilic EsophagitisMirna Chehade0Girish S. Hiremath1Noam Zevit2Salvatore Oliva3Tiffany Pela4Angela Khodzhayev5Juby Jacob-Nara6Amr Radwan7Department of Pediatrics and Medicine, Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York; Correspondence: Address correspondence to: Mirna Chehade, MD, MPH, Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York, New York 10029.Department of Pediatrics, Monroe Carell Jr Children’s Hospital at Vanderbilt, Nashville, TennesseeInstitute of Gastroenterology, Hepatology and Nutrition, Schneider Children's Medical Center of Israel, Petach-Tikva, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, IsraelPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, ItalySanofi, Cambridge, MassachusettsRegeneron Pharmaceuticals Inc, Tarrytown, New YorkSanofi, Cambridge, MassachusettsRegeneron Pharmaceuticals Inc, Tarrytown, New YorkEosinophilic esophagitis (EoE) is a progressive type 2 inflammatory disease characterized by symptoms related to esophageal dysfunction and significant esophageal eosinophilic infiltration. It can affect patients from infancy through adulthood. Pediatric EoE has a multidimensional impact on the quality of life of both patients and their families. Nonspecific symptoms mimicking other gastrointestinal conditions, such as food refusal, failure to thrive, and feeding difficulties, may profoundly affect young children’s eating skills, growth, and psychosocial status, as well as impact family financial conditions. In adolescence, dysphagia and esophageal food impactions often lead to feeding-related anxiety and influence social lives. Delays in diagnosis, arising from lack of awareness among families and clinicians and compensatory eating behaviors, could increase the risk of fibrostenotic complications, which may ultimately add to the symptom burden. Currently available treatment options include proton pump inhibitors, dietary therapies, swallowed topical steroids, esophageal dilation, and biologic therapy. Despite the efficacy of these approaches, disease burden may be further impacted by their limitations, including poor adherence rates, refractory disease, potential long-term safety concerns, and high costs for care. Thus, there is a need for more timely diagnosis in clinical practice and novel targeted disease-modifying therapies better tailored to treat various phenotypes of EoE, aimed at reducing the physical and psychosocial burdens on patients and their caregivers.http://www.sciencedirect.com/science/article/pii/S2772572324001249Eosinophilic EsophagitisDisease BurdenDupilumabPediatricQuality of Life |
| spellingShingle | Mirna Chehade Girish S. Hiremath Noam Zevit Salvatore Oliva Tiffany Pela Angela Khodzhayev Juby Jacob-Nara Amr Radwan Disease Burden and Spectrum of Symptoms That Impact Quality of Life in Pediatric Patients With Eosinophilic Esophagitis Gastro Hep Advances Eosinophilic Esophagitis Disease Burden Dupilumab Pediatric Quality of Life |
| title | Disease Burden and Spectrum of Symptoms That Impact Quality of Life in Pediatric Patients With Eosinophilic Esophagitis |
| title_full | Disease Burden and Spectrum of Symptoms That Impact Quality of Life in Pediatric Patients With Eosinophilic Esophagitis |
| title_fullStr | Disease Burden and Spectrum of Symptoms That Impact Quality of Life in Pediatric Patients With Eosinophilic Esophagitis |
| title_full_unstemmed | Disease Burden and Spectrum of Symptoms That Impact Quality of Life in Pediatric Patients With Eosinophilic Esophagitis |
| title_short | Disease Burden and Spectrum of Symptoms That Impact Quality of Life in Pediatric Patients With Eosinophilic Esophagitis |
| title_sort | disease burden and spectrum of symptoms that impact quality of life in pediatric patients with eosinophilic esophagitis |
| topic | Eosinophilic Esophagitis Disease Burden Dupilumab Pediatric Quality of Life |
| url | http://www.sciencedirect.com/science/article/pii/S2772572324001249 |
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