The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program.

The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program.

Epstein-Barr virus (EBV) uses latency programs to colonize the memory B-cell reservoir, and each program is associated with human malignancies. However, knowledge remains incomplete of epigenetic mechanisms that maintain the highly restricted latency I program, present in memory and Burkitt lymphoma...

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Main Authors: Laura A Murray-Nerger, Davide Maestri, Xiang Liu, Zhixuan Li, Nina R Auld, Italo Tempera, Mingxiang Teng, Benjamin E Gewurz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012525
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https://doi.org/10.1371/journal.ppat.1012525

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