Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study
Abstract Objective To investigate the relationship between the triglyceride-glucose (TyG) index and symptomatic intracranial atherosclerotic stenosis (sICAS) in non-diabetic patients. Methods This retrospective study analyzed 968 nondiabetic acute ischemic stroke (AIS) patients admitted between Janu...
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2025-08-01
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| Online Access: | https://doi.org/10.1186/s12883-025-04324-z |
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| author | Yang Yang Chunhao Mei Xiaoning Guo Bojun Han Qingguang Wang |
| author_facet | Yang Yang Chunhao Mei Xiaoning Guo Bojun Han Qingguang Wang |
| author_sort | Yang Yang |
| collection | DOAJ |
| description | Abstract Objective To investigate the relationship between the triglyceride-glucose (TyG) index and symptomatic intracranial atherosclerotic stenosis (sICAS) in non-diabetic patients. Methods This retrospective study analyzed 968 nondiabetic acute ischemic stroke (AIS) patients admitted between January 2022 and December 2024. Intergroup differences between the sICAS group and the non-sICAS group were analyzed. The TyG index was calculated, and stratified into TyG tertiles (T1–T3). Multivariable logistic regression models adjusted for age, sex, smoking status, alcohol use, hypertension status, BMI, and lipid profiles were used to assess associations with sICAS, stenosis severity, and plaque vulnerability. Restricted cubic splines explore nonlinear relationships. Results Among the 968 included patients, the median age was 58 (IQR 50–66) years, and 43.39% were male. The median TyG index was 8.96 (IQR 8.77, 9.13). Patients with sICAS presented significantly higher total cholesterol (TC) levels and TyG index values, and lower high-density lipoprotein (HDL) levels. The high-TyG group presented a significantly greater prevalence of male, sex, a history of smoking and hypertension, an elevated body mass index (BMI), and lower HDL levels. An elevated TyG index was significantly associated with sICAS, moderate and severe stenosis and vulnerable plaques. This association was maintained after adjusting for age, sex, smoking, alcohol use, hypertension, BMI, TC, HDL, and low-density lipoprotein (LDL) levels. Multivariable-adjusted spline regression models revealed that a progressively increasing risk of sICAS, moderate and severe stenosis and vulnerable plaques was related to an elevated TyG index. Conclusion An elevated TyG index is significantly associated with sICAS and independently associated with severe intracranial arterial stenosis and vulnerable plaques in nondiabetic AIS patients. |
| format | Article |
| id | doaj-art-3a3d88a94c424cf8a9cc1bf5d009ad51 |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-3a3d88a94c424cf8a9cc1bf5d009ad512025-08-20T03:45:52ZengBMCBMC Neurology1471-23772025-08-0125111010.1186/s12883-025-04324-zAssociation between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective studyYang Yang0Chunhao Mei1Xiaoning Guo2Bojun Han3Qingguang Wang4Department of Neurology, Jiangyin Clinical College of Xuzhou Medical UniversityDepartment of Neurology, Jiangyin Clinical College of Xuzhou Medical UniversityDepartment of Neurology, Jiangyin Clinical College of Xuzhou Medical UniversityDepartment of Neurology, Jiangyin Clinical College of Xuzhou Medical UniversityDepartment of Neurology, Jiangyin Clinical College of Xuzhou Medical UniversityAbstract Objective To investigate the relationship between the triglyceride-glucose (TyG) index and symptomatic intracranial atherosclerotic stenosis (sICAS) in non-diabetic patients. Methods This retrospective study analyzed 968 nondiabetic acute ischemic stroke (AIS) patients admitted between January 2022 and December 2024. Intergroup differences between the sICAS group and the non-sICAS group were analyzed. The TyG index was calculated, and stratified into TyG tertiles (T1–T3). Multivariable logistic regression models adjusted for age, sex, smoking status, alcohol use, hypertension status, BMI, and lipid profiles were used to assess associations with sICAS, stenosis severity, and plaque vulnerability. Restricted cubic splines explore nonlinear relationships. Results Among the 968 included patients, the median age was 58 (IQR 50–66) years, and 43.39% were male. The median TyG index was 8.96 (IQR 8.77, 9.13). Patients with sICAS presented significantly higher total cholesterol (TC) levels and TyG index values, and lower high-density lipoprotein (HDL) levels. The high-TyG group presented a significantly greater prevalence of male, sex, a history of smoking and hypertension, an elevated body mass index (BMI), and lower HDL levels. An elevated TyG index was significantly associated with sICAS, moderate and severe stenosis and vulnerable plaques. This association was maintained after adjusting for age, sex, smoking, alcohol use, hypertension, BMI, TC, HDL, and low-density lipoprotein (LDL) levels. Multivariable-adjusted spline regression models revealed that a progressively increasing risk of sICAS, moderate and severe stenosis and vulnerable plaques was related to an elevated TyG index. Conclusion An elevated TyG index is significantly associated with sICAS and independently associated with severe intracranial arterial stenosis and vulnerable plaques in nondiabetic AIS patients.https://doi.org/10.1186/s12883-025-04324-zSymptomatic intracranial atherosclerotic stenosisAcute ischemic strokeInsulin resistanceTriglyceride-glucose indexSevere stenosisVulnerable plaque |
| spellingShingle | Yang Yang Chunhao Mei Xiaoning Guo Bojun Han Qingguang Wang Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study BMC Neurology Symptomatic intracranial atherosclerotic stenosis Acute ischemic stroke Insulin resistance Triglyceride-glucose index Severe stenosis Vulnerable plaque |
| title | Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study |
| title_full | Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study |
| title_fullStr | Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study |
| title_full_unstemmed | Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study |
| title_short | Association between the triglyceride-glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients: a retrospective study |
| title_sort | association between the triglyceride glucose index and symptomatic intracranial atherosclerotic stenosis in nondiabetic patients a retrospective study |
| topic | Symptomatic intracranial atherosclerotic stenosis Acute ischemic stroke Insulin resistance Triglyceride-glucose index Severe stenosis Vulnerable plaque |
| url | https://doi.org/10.1186/s12883-025-04324-z |
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