Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomes
Abstract Clinically, the body mass index remains the most frequently used metric of overall obesity, although it is flawed by its inability to account for different adipose (i.e., visceral, subcutaneous, and inter/intramuscular) compartments, as well as muscle mass. Numerous prior studies have demon...
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| Format: | Article |
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-76280-6 |
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| author | Olesya Mironchuk Andrew L. Chang Farzaneh Rahmani Kaitlyn Portell Elena Nunez Zack Nigogosyan Da Ma Karteek Popuri Vincent Tze Yang Chow Mirza Faisal Beg Jingqin Luo Joseph E. Ippolito |
| author_facet | Olesya Mironchuk Andrew L. Chang Farzaneh Rahmani Kaitlyn Portell Elena Nunez Zack Nigogosyan Da Ma Karteek Popuri Vincent Tze Yang Chow Mirza Faisal Beg Jingqin Luo Joseph E. Ippolito |
| author_sort | Olesya Mironchuk |
| collection | DOAJ |
| description | Abstract Clinically, the body mass index remains the most frequently used metric of overall obesity, although it is flawed by its inability to account for different adipose (i.e., visceral, subcutaneous, and inter/intramuscular) compartments, as well as muscle mass. Numerous prior studies have demonstrated linkages between specific adipose or muscle compartments to outcomes of multiple diseases. Although there are no universally accepted standards for body composition measurement, many studies use a single slice at the L3 vertebral level. In this study, we use computed tomography (CT) studies from patients in The Cancer Genome Atlas (TCGA) to compare current L3-based techniques with volumetric techniques, demonstrating potential limitations with level-based approaches for assessing outcomes. In addition, we identify gene expression signatures in normal kidney that correlate with fat and muscle body composition traits that can be used to predict sex-specific outcomes in renal cell carcinoma. |
| format | Article |
| id | doaj-art-3a3ba372363c4ddfa9e0b2bbc7febbb0 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-3a3ba372363c4ddfa9e0b2bbc7febbb02024-11-10T12:20:45ZengNature PortfolioScientific Reports2045-23222024-11-0114111510.1038/s41598-024-76280-6Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomesOlesya Mironchuk0Andrew L. Chang1Farzaneh Rahmani2Kaitlyn Portell3Elena Nunez4Zack Nigogosyan5Da Ma6Karteek Popuri7Vincent Tze Yang Chow8Mirza Faisal Beg9Jingqin Luo10Joseph E. Ippolito11University of Washington School of MedicineMallinckrodt Institute of Radiology, Washington University in St. Louis School of MedicineMallinckrodt Institute of Radiology, Washington University in St. Louis School of MedicineMallinckrodt Institute of Radiology, Washington University in St. Louis School of MedicineMallinckrodt Institute of Radiology, Washington University in St. Louis School of MedicineMallinckrodt Institute of Radiology, Washington University in St. Louis School of MedicineDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of MedicineDepartment of Computer Science, Memorial University of NewfoundlandSchool of Engineering Science, Simon Fraser UniversitySchool of Engineering Science, Simon Fraser UniversityDivision of Public Health Sciences, Department of Surgery, Siteman Cancer Center Biostatistics and Qualitative Research Shared Resource, Washington University in St. Louis School of MedicineMallinckrodt Institute of Radiology, Washington University in St. Louis School of MedicineAbstract Clinically, the body mass index remains the most frequently used metric of overall obesity, although it is flawed by its inability to account for different adipose (i.e., visceral, subcutaneous, and inter/intramuscular) compartments, as well as muscle mass. Numerous prior studies have demonstrated linkages between specific adipose or muscle compartments to outcomes of multiple diseases. Although there are no universally accepted standards for body composition measurement, many studies use a single slice at the L3 vertebral level. In this study, we use computed tomography (CT) studies from patients in The Cancer Genome Atlas (TCGA) to compare current L3-based techniques with volumetric techniques, demonstrating potential limitations with level-based approaches for assessing outcomes. In addition, we identify gene expression signatures in normal kidney that correlate with fat and muscle body composition traits that can be used to predict sex-specific outcomes in renal cell carcinoma.https://doi.org/10.1038/s41598-024-76280-6 |
| spellingShingle | Olesya Mironchuk Andrew L. Chang Farzaneh Rahmani Kaitlyn Portell Elena Nunez Zack Nigogosyan Da Ma Karteek Popuri Vincent Tze Yang Chow Mirza Faisal Beg Jingqin Luo Joseph E. Ippolito Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomes Scientific Reports |
| title | Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomes |
| title_full | Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomes |
| title_fullStr | Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomes |
| title_full_unstemmed | Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomes |
| title_short | Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomes |
| title_sort | volumetric body composition analysis of the cancer genome atlas reveals novel body composition traits and molecular markers associated with renal carcinoma outcomes |
| url | https://doi.org/10.1038/s41598-024-76280-6 |
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