Sepsis Induces Long‐Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A

Sepsis Induces Long‐Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A

ABSTRACT Background Sepsis survivors often experience sustained muscle weakness, leading to physical disability, with no pharmacological treatments available. Despite these well‐documented long‐term clinical consequences, research exploring the cellular and molecular mechanisms is sorely lacking. Me...

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Main Authors: Alexandre Pierre, Raphael Favory, Benoit Brassart, Claire Bourel, Raphael Romien, Sylvain Normandin, Arthur Dubech, Claire Vincent, Jeremy Lemaire, Gaelle Grolaux, Ophelie Not, Frederic Wallet, Frederic Daussin, Eric Boulanger, Arthur Durand, Marie Frimat, Alina Ghinet, Michael Howsam, William Laine, Philippe Marchetti, Jerome Kluza, Estelle Chatelain, Jimmy Vandel, Nicolas Barois, Valerie Montel, Bruno Bastide, Sebastien Preau, Steve Lancel
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
autophagy
mitochondria
muscle
sepsis
Online Access:https://doi.org/10.1002/jcsm.70041
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