Edible Tagetes patula Flower and Its Flavanoid Patuletin: Pre-clinical Evidence of Selective Systemic Toxicity
Background: Phytotherapy is a common practice around the world, including Pakistan. One such medicinal plant is Tagetes patula. Its flower is edible and used for various local illnesses, especially cancer. However, they lack the toxicological evaluation of this plant, including its active flavonoid...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shaheed Beheshti University of Medical Sciences
2025-01-01
|
| Series: | International Journal of Medical Toxicology and Forensic Medicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/ijmtfm/article/view/46416/34385 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849335980952125440 |
|---|---|
| author | Muhammad Kashif Hazar Khan Asma Khawer Hafiz Syed Imran ul Haq Muhammad Aitmaud Uddolah Khan Mudassar Azhar Shaheen Faizi Ahsana Dar Farooq |
| author_facet | Muhammad Kashif Hazar Khan Asma Khawer Hafiz Syed Imran ul Haq Muhammad Aitmaud Uddolah Khan Mudassar Azhar Shaheen Faizi Ahsana Dar Farooq |
| author_sort | Muhammad Kashif |
| collection | DOAJ |
| description | Background: Phytotherapy is a common practice around the world, including Pakistan. One such medicinal plant is Tagetes patula. Its flower is edible and used for various local illnesses, especially cancer. However, they lack the toxicological evaluation of this plant, including its active flavonoid i.e. Patuletin, which is addressed in the present investigation.
Methods: Wistar rats of either sex (150 g) were intraperitoneally treated (acute [1 day], sub-acute [7 days], and repeated dose [28 days]) with T. patula flower methanolic extract (1 and 2 g/kg) and patuletin (5, 30 and 60 mg/kg). Weight changes in rats were observed. Additionally, the hematological and biochemical (hepatic and renal function) indicators were assessed using respective analyzers. Histological examination of the liver and kidney was also performed following hematoxylin and eosin staining.
Results: Our data showed that none of the treatments caused a significant alteration in the weight of rats compared to the control. Among the various hematological parameters, the white blood cell count was significantly reduced by both extract and patuletin treatments. However, the enhanced levels of aspartate aminotransferase along with morphological changes in the liver were observed only in patuletin-exposed animals.
Conclusion: The present study demonstrated the toxic potential of T. patula flower methanolic extract and its active flavonoid i.e. patuletin. It further recommends the implementation of a regulatory check over its consumption to protect fellow citizens from the harmful effects.
|
| format | Article |
| id | doaj-art-3a2fde9c1f1b4d69ab3d23a0cc180489 |
| institution | Kabale University |
| issn | 2251-8762 2251-8770 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Shaheed Beheshti University of Medical Sciences |
| record_format | Article |
| series | International Journal of Medical Toxicology and Forensic Medicine |
| spelling | doaj-art-3a2fde9c1f1b4d69ab3d23a0cc1804892025-08-20T03:45:07ZengShaheed Beheshti University of Medical SciencesInternational Journal of Medical Toxicology and Forensic Medicine2251-87622251-87702025-01-01151Edible Tagetes patula Flower and Its Flavanoid Patuletin: Pre-clinical Evidence of Selective Systemic ToxicityMuhammad KashifHazar KhanAsma KhawerHafiz Syed Imran ul HaqMuhammad Aitmaud Uddolah KhanMudassar AzharShaheen FaiziAhsana Dar FarooqBackground: Phytotherapy is a common practice around the world, including Pakistan. One such medicinal plant is Tagetes patula. Its flower is edible and used for various local illnesses, especially cancer. However, they lack the toxicological evaluation of this plant, including its active flavonoid i.e. Patuletin, which is addressed in the present investigation. Methods: Wistar rats of either sex (150 g) were intraperitoneally treated (acute [1 day], sub-acute [7 days], and repeated dose [28 days]) with T. patula flower methanolic extract (1 and 2 g/kg) and patuletin (5, 30 and 60 mg/kg). Weight changes in rats were observed. Additionally, the hematological and biochemical (hepatic and renal function) indicators were assessed using respective analyzers. Histological examination of the liver and kidney was also performed following hematoxylin and eosin staining. Results: Our data showed that none of the treatments caused a significant alteration in the weight of rats compared to the control. Among the various hematological parameters, the white blood cell count was significantly reduced by both extract and patuletin treatments. However, the enhanced levels of aspartate aminotransferase along with morphological changes in the liver were observed only in patuletin-exposed animals. Conclusion: The present study demonstrated the toxic potential of T. patula flower methanolic extract and its active flavonoid i.e. patuletin. It further recommends the implementation of a regulatory check over its consumption to protect fellow citizens from the harmful effects. https://journals.sbmu.ac.ir/ijmtfm/article/view/46416/34385tagetes patula flowerpatuletinwhite blood cells (wbc)hepatotoxicity |
| spellingShingle | Muhammad Kashif Hazar Khan Asma Khawer Hafiz Syed Imran ul Haq Muhammad Aitmaud Uddolah Khan Mudassar Azhar Shaheen Faizi Ahsana Dar Farooq Edible Tagetes patula Flower and Its Flavanoid Patuletin: Pre-clinical Evidence of Selective Systemic Toxicity International Journal of Medical Toxicology and Forensic Medicine tagetes patula flower patuletin white blood cells (wbc) hepatotoxicity |
| title | Edible Tagetes patula Flower and Its Flavanoid Patuletin: Pre-clinical Evidence of Selective Systemic Toxicity |
| title_full | Edible Tagetes patula Flower and Its Flavanoid Patuletin: Pre-clinical Evidence of Selective Systemic Toxicity |
| title_fullStr | Edible Tagetes patula Flower and Its Flavanoid Patuletin: Pre-clinical Evidence of Selective Systemic Toxicity |
| title_full_unstemmed | Edible Tagetes patula Flower and Its Flavanoid Patuletin: Pre-clinical Evidence of Selective Systemic Toxicity |
| title_short | Edible Tagetes patula Flower and Its Flavanoid Patuletin: Pre-clinical Evidence of Selective Systemic Toxicity |
| title_sort | edible tagetes patula flower and its flavanoid patuletin pre clinical evidence of selective systemic toxicity |
| topic | tagetes patula flower patuletin white blood cells (wbc) hepatotoxicity |
| url | https://journals.sbmu.ac.ir/ijmtfm/article/view/46416/34385 |
| work_keys_str_mv | AT muhammadkashif edibletagetespatulafloweranditsflavanoidpatuletinpreclinicalevidenceofselectivesystemictoxicity AT hazarkhan edibletagetespatulafloweranditsflavanoidpatuletinpreclinicalevidenceofselectivesystemictoxicity AT asmakhawer edibletagetespatulafloweranditsflavanoidpatuletinpreclinicalevidenceofselectivesystemictoxicity AT hafizsyedimranulhaq edibletagetespatulafloweranditsflavanoidpatuletinpreclinicalevidenceofselectivesystemictoxicity AT muhammadaitmaududdolahkhan edibletagetespatulafloweranditsflavanoidpatuletinpreclinicalevidenceofselectivesystemictoxicity AT mudassarazhar edibletagetespatulafloweranditsflavanoidpatuletinpreclinicalevidenceofselectivesystemictoxicity AT shaheenfaizi edibletagetespatulafloweranditsflavanoidpatuletinpreclinicalevidenceofselectivesystemictoxicity AT ahsanadarfarooq edibletagetespatulafloweranditsflavanoidpatuletinpreclinicalevidenceofselectivesystemictoxicity |