Overexpression of PTPN21 promotes proliferation of EGF-stimulated acute lymphoblastic leukemia cells via the MAPK signaling pathways

Overexpression of PTPN21 promotes proliferation of EGF-stimulated acute lymphoblastic leukemia cells via the MAPK signaling pathways

Objectives This study aims to investigate the role of excessive Protein Tyrosine Phosphatase Non-Receptor Type 21 (PTPN21) in the proliferation of Acute Lymphoblastic Leukemia (ALL) cells with EGF stimulation.Methods PTPN21 was overexpressed in ALL cell lines by lentiviral transfection. Apoptosis wa...

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Bibliographic Details
Main Authors: Ni Zhu, Jieping Wei, Li-Mengmeng Wang, He Huang, Haowen Xiao
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Hematology
Subjects:
Acute lymphoblastic leukemia
PTPN21
proliferation
Src
MAPK signal pathways
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2024.2356292
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