Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer
Triple-negative breast cancer (TNBC) stands as the most complex and daunting subtype of breast cancer affecting women globally. Regrettably, treatment options for TNBC remain limited due to its clinical complexity. However, immunotherapy has emerged as a promising avenue, showing success in developi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1455211/full |
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| author | Desh Deepak Singh Shafiul Haque Youngsun Kim Ihn Han Dharmendra Kumar Yadav |
| author_facet | Desh Deepak Singh Shafiul Haque Youngsun Kim Ihn Han Dharmendra Kumar Yadav |
| author_sort | Desh Deepak Singh |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) stands as the most complex and daunting subtype of breast cancer affecting women globally. Regrettably, treatment options for TNBC remain limited due to its clinical complexity. However, immunotherapy has emerged as a promising avenue, showing success in developing effective therapies for advanced cases and improving patient outcomes. Improving TNBC treatments involves reducing side effects, minimizing systemic toxicity, and enhancing efficacy. Unlike traditional cancer immunotherapy, engineered nonmaterial’s can precisely target TNBC, facilitating immune cell access, improving antigen presentation, and triggering lasting immune responses. Nanocarriers with enhanced sensitivity and specificity, specific cellular absorption, and low toxicity are gaining attention. Nanotechnology-driven immunoengineering strategies focus on targeted delivery systems using multifunctional molecules for precise tracking, diagnosis, and therapy in TNBC. This study delves into TNBC’s tumour microenvironment (TME) remodeling, therapeutic resistance, and immunoengineering strategies using nanotechnology. |
| format | Article |
| id | doaj-art-3a1a8d855b1b4e078ad6ab1d9be43fa2 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3a1a8d855b1b4e078ad6ab1d9be43fa22024-12-10T06:33:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14552111455211Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancerDesh Deepak Singh0Shafiul Haque1Youngsun Kim2Ihn Han3Dharmendra Kumar Yadav4Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, IndiaResearch and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi ArabiaDepartment of Obstetrics and Gynecology, Kyung Hee University Medical Center, Seoul, Republic of KoreaPlasma Bioscience Research Center, Applied Plasma Medicine Center, Department of Electrical & Biological Physics, Kwangwoon University, Seoul, Republic of KoreaDepartment of Biologics, College of Pharmacy, Hambakmoeiro 191, Yeonsu-gu, Incheon, Republic of KoreaTriple-negative breast cancer (TNBC) stands as the most complex and daunting subtype of breast cancer affecting women globally. Regrettably, treatment options for TNBC remain limited due to its clinical complexity. However, immunotherapy has emerged as a promising avenue, showing success in developing effective therapies for advanced cases and improving patient outcomes. Improving TNBC treatments involves reducing side effects, minimizing systemic toxicity, and enhancing efficacy. Unlike traditional cancer immunotherapy, engineered nonmaterial’s can precisely target TNBC, facilitating immune cell access, improving antigen presentation, and triggering lasting immune responses. Nanocarriers with enhanced sensitivity and specificity, specific cellular absorption, and low toxicity are gaining attention. Nanotechnology-driven immunoengineering strategies focus on targeted delivery systems using multifunctional molecules for precise tracking, diagnosis, and therapy in TNBC. This study delves into TNBC’s tumour microenvironment (TME) remodeling, therapeutic resistance, and immunoengineering strategies using nanotechnology.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1455211/fulltriple negative breast cancerimmunotherapytumor microenvironmentdrug resistancenanomedicine |
| spellingShingle | Desh Deepak Singh Shafiul Haque Youngsun Kim Ihn Han Dharmendra Kumar Yadav Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer Frontiers in Immunology triple negative breast cancer immunotherapy tumor microenvironment drug resistance nanomedicine |
| title | Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer |
| title_full | Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer |
| title_fullStr | Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer |
| title_full_unstemmed | Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer |
| title_short | Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer |
| title_sort | remodeling of tumour microenvironment strategies to overcome therapeutic resistance and innovate immunoengineering in triple negative breast cancer |
| topic | triple negative breast cancer immunotherapy tumor microenvironment drug resistance nanomedicine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1455211/full |
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