Design, synthesis, α-glucosidase inhibition and hypoglycemic activity of 3-aceto(benzo)hydrazide-1,2,4-triazines as potential anti-diabetic agents

Design, synthesis, α-glucosidase inhibition and hypoglycemic activity of 3-aceto(benzo)hydrazide-1,2,4-triazines as potential anti-diabetic agents

Type 2 diabetes is a common condition that causes the level of glucose in the blood to become too high and α-glucosidase inhibitors are therapeutic agents in managing type 2 diabetes. In the present study, we report a new series of 3-aceto(benzo)hydrazide-1,2,4-triazine analogs as potential therapeu...

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Bibliographic Details
Main Authors: Mehdi Valipour, Zahra Zakeri Khatir, Kaveh Kiadaliry, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Mohammad Shokati Sayyad, Mohammad Seyedabadi, Majid Ghasemian, Seyedeh Mahdieh Hashemi, Hamid Irannejad
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Diabetes mellitus
1,2,4-Triazine
Synthesis
α-glucosidase
Hyperglycemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424000797
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