HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1

HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1

ABSTRACT We previously reported that hepatitis C virus (HCV) infection or HCV core protein expression induces HOX gene expression by impairing histone H2A monoubiquitination via a proteasome-dependent reduction in the level of RNF2, a key catalytic component of polycomb repressive complex 1 (H. Kasa...

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Bibliographic Details
Main Authors: Hirotake Kasai, Atsuya Yamashita, Yasunori Akaike, Tomohisa Tanaka, Yoshiharu Matsuura, Kohji Moriishi
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
HCV
RNF2
H2A monoubiquitination
PA28γ/REGγ/PMSE3/Ki
Online Access:https://journals.asm.org/doi/10.1128/mbio.01691-24
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