Alpha–lipoic acid supplementation improves pathological alterations in cellular models of Friedreich ataxia

Alpha–lipoic acid supplementation improves pathological alterations in cellular models of Friedreich ataxia

Abstract Background Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and an increased incidence of diabetes. The underlying pathophysiological mechanism of FRDA, driven by a...

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Main Authors: Marta Talaverón-Rey, Diana Reche-López, Suleva Povea-Cabello, Mónica Álvarez-Córdoba, David Gómez-Fernández, Ana Romero-González, Paula Cilleros-Holgado, José Manuel Romero-Domínguez, Alejandra López-Cabrera, Rocío Piñero-Pérez, Susana González-Granero, José Manuel García-Verdugo, José A. Sánchez-Alcázar
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Friedreich ataxia
Frataxin
Mitochondria
Iron accumulation
Fibroblasts
Induced neurons
Online Access:https://doi.org/10.1186/s13023-025-03990-z
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https://doi.org/10.1186/s13023-025-03990-z

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