Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection
The human gastrointestinal tract is colonized by a complex microbial ecosystem, the gut microbiota, which is pivotal in maintaining host health and mediating resistance to diseases. This review delineates colonization resistance (CR), a critical defensive mechanism employed by the gut microbiota to...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2424914 |
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| _version_ | 1846172941898743808 |
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| author | Lei Deng Shaohui Wang |
| author_facet | Lei Deng Shaohui Wang |
| author_sort | Lei Deng |
| collection | DOAJ |
| description | The human gastrointestinal tract is colonized by a complex microbial ecosystem, the gut microbiota, which is pivotal in maintaining host health and mediating resistance to diseases. This review delineates colonization resistance (CR), a critical defensive mechanism employed by the gut microbiota to safeguard against pathogenic bacterial invasions, notably by Salmonella. We detail the mechanisms through which the gut microbiota impedes Salmonella colonization, including nutrient competition, production of antimicrobial peptides, synthesis of microbial-derived metabolites, and modulation of the host immune response. Additionally, we examine how dietary interventions can influence these mechanisms, thereby augmenting the protective role of the gut microbiota. The review also discusses the sophisticated strategies utilized by Salmonella to overcome these microbial defenses. A thorough understanding of these complex interactions between microbial symbionts and pathogens is crucial for the development of innovative therapeutic strategies that enhance CR, aiming to prevent or treat microbial infections effectively. |
| format | Article |
| id | doaj-art-39dfff531ee8470e9fc6f6b715e26a2c |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-39dfff531ee8470e9fc6f6b715e26a2c2024-11-08T18:31:47ZengTaylor & Francis GroupGut Microbes1949-09761949-09842024-12-0116110.1080/19490976.2024.2424914Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infectionLei Deng0Shaohui Wang1Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, ChinaThe human gastrointestinal tract is colonized by a complex microbial ecosystem, the gut microbiota, which is pivotal in maintaining host health and mediating resistance to diseases. This review delineates colonization resistance (CR), a critical defensive mechanism employed by the gut microbiota to safeguard against pathogenic bacterial invasions, notably by Salmonella. We detail the mechanisms through which the gut microbiota impedes Salmonella colonization, including nutrient competition, production of antimicrobial peptides, synthesis of microbial-derived metabolites, and modulation of the host immune response. Additionally, we examine how dietary interventions can influence these mechanisms, thereby augmenting the protective role of the gut microbiota. The review also discusses the sophisticated strategies utilized by Salmonella to overcome these microbial defenses. A thorough understanding of these complex interactions between microbial symbionts and pathogens is crucial for the development of innovative therapeutic strategies that enhance CR, aiming to prevent or treat microbial infections effectively.https://www.tandfonline.com/doi/10.1080/19490976.2024.2424914Gut microbiotacolonization resistanceSalmonellaimmune responsedietary intervention |
| spellingShingle | Lei Deng Shaohui Wang Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection Gut Microbes Gut microbiota colonization resistance Salmonella immune response dietary intervention |
| title | Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection |
| title_full | Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection |
| title_fullStr | Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection |
| title_full_unstemmed | Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection |
| title_short | Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection |
| title_sort | colonization resistance the role of gut microbiota in preventing salmonella invasion and infection |
| topic | Gut microbiota colonization resistance Salmonella immune response dietary intervention |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2424914 |
| work_keys_str_mv | AT leideng colonizationresistancetheroleofgutmicrobiotainpreventingsalmonellainvasionandinfection AT shaohuiwang colonizationresistancetheroleofgutmicrobiotainpreventingsalmonellainvasionandinfection |