Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies
Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5376476 |
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| _version_ | 1841524610963603456 |
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| author | Chau Yee Ng Chun-Bing Chen Ming-Ying Wu Jennifer Wu Chih-Hsun Yang Rosaline Chung-Yee Hui Ya-Ching Chang Chun-Wei Lu |
| author_facet | Chau Yee Ng Chun-Bing Chen Ming-Ying Wu Jennifer Wu Chih-Hsun Yang Rosaline Chung-Yee Hui Ya-Ching Chang Chun-Wei Lu |
| author_sort | Chau Yee Ng |
| collection | DOAJ |
| description | Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) with increase morbidity and mortality while they are receiving cancer treatments, have been proposed to be a result of direct skin toxicity or drug hypersensitivity reactions (these are proposed mechanism, not definite). Differentiating SCARs from other more commonly seen reactions with a better outcome help prevent discontinuation of therapy and inappropriate use of systemic immunosuppressants for presumable allergic reactions, of which will affect the clinical outcome. In this article, we have reviewed published articles from 1950 to August 2017 for SJS/TEN associated with anticancer drugs, including chemotherapy, targeted therapy, and immunotherapy. We aimed to provide an overview of SJS/TEN associated with anticancer drugs to increase clinician recognition and accelerate future studies on the pathomechanism and managements. |
| format | Article |
| id | doaj-art-39d53496e86840cab4c678b895e5d51a |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-39d53496e86840cab4c678b895e5d51a2025-02-03T05:47:45ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/53764765376476Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or ImmunotherapiesChau Yee Ng0Chun-Bing Chen1Ming-Ying Wu2Jennifer Wu3Chih-Hsun Yang4Rosaline Chung-Yee Hui5Ya-Ching Chang6Chun-Wei Lu7Department of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, TaiwanDepartment of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, TaiwanDepartment of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, TaiwanDepartment of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, TaiwanDepartment of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, TaiwanDepartment of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, TaiwanDepartment of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, TaiwanDepartment of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, TaiwanCutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) with increase morbidity and mortality while they are receiving cancer treatments, have been proposed to be a result of direct skin toxicity or drug hypersensitivity reactions (these are proposed mechanism, not definite). Differentiating SCARs from other more commonly seen reactions with a better outcome help prevent discontinuation of therapy and inappropriate use of systemic immunosuppressants for presumable allergic reactions, of which will affect the clinical outcome. In this article, we have reviewed published articles from 1950 to August 2017 for SJS/TEN associated with anticancer drugs, including chemotherapy, targeted therapy, and immunotherapy. We aimed to provide an overview of SJS/TEN associated with anticancer drugs to increase clinician recognition and accelerate future studies on the pathomechanism and managements.http://dx.doi.org/10.1155/2018/5376476 |
| spellingShingle | Chau Yee Ng Chun-Bing Chen Ming-Ying Wu Jennifer Wu Chih-Hsun Yang Rosaline Chung-Yee Hui Ya-Ching Chang Chun-Wei Lu Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies Journal of Immunology Research |
| title | Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies |
| title_full | Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies |
| title_fullStr | Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies |
| title_full_unstemmed | Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies |
| title_short | Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies |
| title_sort | anticancer drugs induced severe adverse cutaneous drug reactions an updated review on the risks associated with anticancer targeted therapy or immunotherapies |
| url | http://dx.doi.org/10.1155/2018/5376476 |
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