Is It Primary Carcinoma or Lymphoma Breast: Re-emphasizing the Value of Tissue Diagnosis in a Challenging Case Presenting With Pulmonary Thromboembolism
Primary lymphoma of the breast is an uncommon entity with a prevalence of 1%–2% of non-Hodgkin’s lymphomas. Most of them are B-cell type (50% of all malignant breast lymphomas). We present the case of a 53-year-old female, who reported with 20 cm × 15 cm gradually progressive lump in the right breas...
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| Language: | English |
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Wolters Kluwer Medknow Publications
2024-11-01
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| Series: | CHRISMED Journal of Health and Research |
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| Online Access: | https://journals.lww.com/10.4103/cjhr.cjhr_26_24 |
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| author | Gurpreet Kaur Walia Surjeet Dwivedi Arijit Datta Ramanjit Singh Akal |
| author_facet | Gurpreet Kaur Walia Surjeet Dwivedi Arijit Datta Ramanjit Singh Akal |
| author_sort | Gurpreet Kaur Walia |
| collection | DOAJ |
| description | Primary lymphoma of the breast is an uncommon entity with a prevalence of 1%–2% of non-Hodgkin’s lymphomas. Most of them are B-cell type (50% of all malignant breast lymphomas). We present the case of a 53-year-old female, who reported with 20 cm × 15 cm gradually progressive lump in the right breast for 2 months, involving the entire right breast. Positron emission tomography scan confirmed a metabolically active mass lesion in the right breast. Trucut biopsy of the lump revealed an infiltrating tumor arranged in diffuse sheets. Tumor cells were large with scant cytoplasm, high N:C ratio, and hyperchromatic nuclei. Immunohistochemistry showed CD20, bcl2, bcl6, and CD10 positive in tumor cells, whereas CD3 and MUM1 were negative. A final opinion of diffuse large B-cell lymphoma-germinal center type was given. The patient was managed with six cycles of chemotherapy with R-CHOP, every 3 weeks. She was followed up for a period of 1 year and remained asymptomatic. |
| format | Article |
| id | doaj-art-39d455a8d7c84172aeb1c2f8049157ee |
| institution | Kabale University |
| issn | 2348-3334 2348-506X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | CHRISMED Journal of Health and Research |
| spelling | doaj-art-39d455a8d7c84172aeb1c2f8049157ee2024-12-06T06:00:51ZengWolters Kluwer Medknow PublicationsCHRISMED Journal of Health and Research2348-33342348-506X2024-11-0111212212410.4103/cjhr.cjhr_26_24Is It Primary Carcinoma or Lymphoma Breast: Re-emphasizing the Value of Tissue Diagnosis in a Challenging Case Presenting With Pulmonary ThromboembolismGurpreet Kaur WaliaSurjeet DwivediArijit DattaRamanjit Singh AkalPrimary lymphoma of the breast is an uncommon entity with a prevalence of 1%–2% of non-Hodgkin’s lymphomas. Most of them are B-cell type (50% of all malignant breast lymphomas). We present the case of a 53-year-old female, who reported with 20 cm × 15 cm gradually progressive lump in the right breast for 2 months, involving the entire right breast. Positron emission tomography scan confirmed a metabolically active mass lesion in the right breast. Trucut biopsy of the lump revealed an infiltrating tumor arranged in diffuse sheets. Tumor cells were large with scant cytoplasm, high N:C ratio, and hyperchromatic nuclei. Immunohistochemistry showed CD20, bcl2, bcl6, and CD10 positive in tumor cells, whereas CD3 and MUM1 were negative. A final opinion of diffuse large B-cell lymphoma-germinal center type was given. The patient was managed with six cycles of chemotherapy with R-CHOP, every 3 weeks. She was followed up for a period of 1 year and remained asymptomatic.https://journals.lww.com/10.4103/cjhr.cjhr_26_24breastimmunohistochemistrylymphomanon-hodgkin |
| spellingShingle | Gurpreet Kaur Walia Surjeet Dwivedi Arijit Datta Ramanjit Singh Akal Is It Primary Carcinoma or Lymphoma Breast: Re-emphasizing the Value of Tissue Diagnosis in a Challenging Case Presenting With Pulmonary Thromboembolism CHRISMED Journal of Health and Research breast immunohistochemistry lymphoma non-hodgkin |
| title | Is It Primary Carcinoma or Lymphoma Breast: Re-emphasizing the Value of Tissue Diagnosis in a Challenging Case Presenting With Pulmonary Thromboembolism |
| title_full | Is It Primary Carcinoma or Lymphoma Breast: Re-emphasizing the Value of Tissue Diagnosis in a Challenging Case Presenting With Pulmonary Thromboembolism |
| title_fullStr | Is It Primary Carcinoma or Lymphoma Breast: Re-emphasizing the Value of Tissue Diagnosis in a Challenging Case Presenting With Pulmonary Thromboembolism |
| title_full_unstemmed | Is It Primary Carcinoma or Lymphoma Breast: Re-emphasizing the Value of Tissue Diagnosis in a Challenging Case Presenting With Pulmonary Thromboembolism |
| title_short | Is It Primary Carcinoma or Lymphoma Breast: Re-emphasizing the Value of Tissue Diagnosis in a Challenging Case Presenting With Pulmonary Thromboembolism |
| title_sort | is it primary carcinoma or lymphoma breast re emphasizing the value of tissue diagnosis in a challenging case presenting with pulmonary thromboembolism |
| topic | breast immunohistochemistry lymphoma non-hodgkin |
| url | https://journals.lww.com/10.4103/cjhr.cjhr_26_24 |
| work_keys_str_mv | AT gurpreetkaurwalia isitprimarycarcinomaorlymphomabreastreemphasizingthevalueoftissuediagnosisinachallengingcasepresentingwithpulmonarythromboembolism AT surjeetdwivedi isitprimarycarcinomaorlymphomabreastreemphasizingthevalueoftissuediagnosisinachallengingcasepresentingwithpulmonarythromboembolism AT arijitdatta isitprimarycarcinomaorlymphomabreastreemphasizingthevalueoftissuediagnosisinachallengingcasepresentingwithpulmonarythromboembolism AT ramanjitsinghakal isitprimarycarcinomaorlymphomabreastreemphasizingthevalueoftissuediagnosisinachallengingcasepresentingwithpulmonarythromboembolism |