Relationship of endothelial dysfunction with degree of renal function damage and lipidemic profile in patients with type 2 diabetes mellitus and hypertension
In the article defining relationship between endothelial dysfunction, the degree of renal and lipidemic profile damage in 234 patients with type 2 diabetes mellitus with hypertension was carried depending on the quality of glycemic control. It is shown that the deepening of endothelial dysfunction i...
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| Format: | Article |
| Language: | English |
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Dnipro State Medical University
2014-09-01
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| Series: | Medičnì Perspektivi |
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| Online Access: | http://medpers.dsma.dp.ua/issues/2014/N3/36-43.pdf |
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| author | Pertseva N.O. |
| author_facet | Pertseva N.O. |
| author_sort | Pertseva N.O. |
| collection | DOAJ |
| description | In the article defining relationship between endothelial dysfunction, the degree of renal and lipidemic profile damage in 234 patients with type 2 diabetes mellitus with hypertension was carried depending on the quality of glycemic control. It is shown that the deepening of endothelial dysfunction in patients with insufficient and poor compensation tightly correlates with the degree of renal and lipidemic disorders. In these patients there was a significant increase in the level of albuminuria, reduction in glomerular filtration rate, increase of concentrations of urea and creatinine. Against the background of poor hyperglycemia, compensation total cholesterol, low density lipoprotein content increases by 73,3% (p<0.05), hype¬rtriglyceridemia twice exceeds the control values. In patients with type 2 diabetes mellitus with poor compensation the most significant correlation links were observed between the concentration of endothelin-1 and the level of microalbuminuria (r=+0,79), as well as the content of low density lipoprotein cholesterol (r=+0.81). Thrombomodulin concentration is in direct correlation with microalbuminuria (r=+0.76), hypercholesterolemia (r=+0.80) and hypertriglyceridemia (r=+0.83), indicating to increasing interaction between the pathogenetic mechanisms which cause depression of endothelial dysfunction, renal and dyslipidemic disorders with increasing hyperglycemia. |
| format | Article |
| id | doaj-art-39ad63b11f4d4ce1aadb16f5bcd9b4c2 |
| institution | Kabale University |
| issn | 2307-0404 2307-0404 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-39ad63b11f4d4ce1aadb16f5bcd9b4c22024-12-02T01:09:56ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042014-09-011933643Relationship of endothelial dysfunction with degree of renal function damage and lipidemic profile in patients with type 2 diabetes mellitus and hypertensionPertseva N.O. 0SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»In the article defining relationship between endothelial dysfunction, the degree of renal and lipidemic profile damage in 234 patients with type 2 diabetes mellitus with hypertension was carried depending on the quality of glycemic control. It is shown that the deepening of endothelial dysfunction in patients with insufficient and poor compensation tightly correlates with the degree of renal and lipidemic disorders. In these patients there was a significant increase in the level of albuminuria, reduction in glomerular filtration rate, increase of concentrations of urea and creatinine. Against the background of poor hyperglycemia, compensation total cholesterol, low density lipoprotein content increases by 73,3% (p<0.05), hype¬rtriglyceridemia twice exceeds the control values. In patients with type 2 diabetes mellitus with poor compensation the most significant correlation links were observed between the concentration of endothelin-1 and the level of microalbuminuria (r=+0,79), as well as the content of low density lipoprotein cholesterol (r=+0.81). Thrombomodulin concentration is in direct correlation with microalbuminuria (r=+0.76), hypercholesterolemia (r=+0.80) and hypertriglyceridemia (r=+0.83), indicating to increasing interaction between the pathogenetic mechanisms which cause depression of endothelial dysfunction, renal and dyslipidemic disorders with increasing hyperglycemia.http://medpers.dsma.dp.ua/issues/2014/N3/36-43.pdfdiabetes mellitus type 2arterial hypertensionendothelial dysfunctionrenal functionlipidemic profilerelationship |
| spellingShingle | Pertseva N.O. Relationship of endothelial dysfunction with degree of renal function damage and lipidemic profile in patients with type 2 diabetes mellitus and hypertension Medičnì Perspektivi diabetes mellitus type 2 arterial hypertension endothelial dysfunction renal function lipidemic profile relationship |
| title | Relationship of endothelial dysfunction with degree of renal function damage and lipidemic profile in patients with type 2 diabetes mellitus and hypertension |
| title_full | Relationship of endothelial dysfunction with degree of renal function damage and lipidemic profile in patients with type 2 diabetes mellitus and hypertension |
| title_fullStr | Relationship of endothelial dysfunction with degree of renal function damage and lipidemic profile in patients with type 2 diabetes mellitus and hypertension |
| title_full_unstemmed | Relationship of endothelial dysfunction with degree of renal function damage and lipidemic profile in patients with type 2 diabetes mellitus and hypertension |
| title_short | Relationship of endothelial dysfunction with degree of renal function damage and lipidemic profile in patients with type 2 diabetes mellitus and hypertension |
| title_sort | relationship of endothelial dysfunction with degree of renal function damage and lipidemic profile in patients with type 2 diabetes mellitus and hypertension |
| topic | diabetes mellitus type 2 arterial hypertension endothelial dysfunction renal function lipidemic profile relationship |
| url | http://medpers.dsma.dp.ua/issues/2014/N3/36-43.pdf |
| work_keys_str_mv | AT pertsevano relationshipofendothelialdysfunctionwithdegreeofrenalfunctiondamageandlipidemicprofileinpatientswithtype2diabetesmellitusandhypertension |