Investigation of triiodothyronine, thyroxine, and thyroid-stimulating hormone levels’ influence on atrial myocardial electrical instability in experimental hypothyroidism
BACKGROUND: Identifying the association between thyroid dysfunction and the development of nonvalvular atrial fibrillation (AF) remains one of the complex and pressing issue in contemporary cardiology. To date, only a limited number of studies have examined the relationship between AF and the hypoth...
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| Format: | Article |
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Concilium Medicum
2025-01-01
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| Series: | КардиоСоматика |
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| Online Access: | https://cardiosomatics.ru/2221-7185/article/viewFile/676542/204317 |
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| author | Ruslan F. Rakhmatullov Renata E. Dementeva Alina E. Sheina Kristina P. Kondrateva Fagim K. Rakhmatullov Ludmila V. Melnikova |
| author_facet | Ruslan F. Rakhmatullov Renata E. Dementeva Alina E. Sheina Kristina P. Kondrateva Fagim K. Rakhmatullov Ludmila V. Melnikova |
| author_sort | Ruslan F. Rakhmatullov |
| collection | DOAJ |
| description | BACKGROUND: Identifying the association between thyroid dysfunction and the development of nonvalvular atrial fibrillation (AF) remains one of the complex and pressing issue in contemporary cardiology. To date, only a limited number of studies have examined the relationship between AF and the hypothalamic-pituitary-thyroid (HPT) axis, and the available findings are often contradictory. Few papers have explored the association between AF and HPT axis in experimental conditions.
AIM: The work aimed to evaluate the association between AF and the HPT axis in experimental models of hypothyroidism, euthyroidism, and thyrotoxicosis in rats.
METHODS: The study included 146 outbred rats. Group 1 comprised 42 rats with euthyroidism. Group 2 included 15 rats with overt thyrotoxicosis. Group 3 included 22 rats with subclinical thyrotoxicosis. Group 4 comprised 67 rats with euthyroid sick syndrome. The methods included electrocardiographic monitoring and measurement of thyroid hormone concentrations.
RESULTS: The frequency of AF paroxysms was found to depend on thyroid hormone levels: under euthyroid conditions, on thyroid-stimulating hormone (β = −0.250; p 0.001) and thyroxine (β = 0.838; p = 0.012); in overt thyrotoxicosis, on thyroxine (β = 0.732; p = 0.00008) and triiodothyronine (β = 0.352; p = 0.043); and in subclinical thyrotoxicosis, on thyroxine (β = 2.1; p = 0.0002) and triiodothyronine (β = −0.970; p = 0.019). Threshold values of thyroid hormones were determined for euthyroid, subclinical, and overt thyrotoxic states.
CONCLUSION: A relationship between atrial fibrillation and thyroid functional status was established. |
| format | Article |
| id | doaj-art-39a48ca1c9354806a8d8da51a7b15a86 |
| institution | Kabale University |
| issn | 2221-7185 2658-5707 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Concilium Medicum |
| record_format | Article |
| series | КардиоСоматика |
| spelling | doaj-art-39a48ca1c9354806a8d8da51a7b15a862025-08-20T03:43:51ZengConcilium MedicumКардиоСоматика2221-71852658-57072025-01-0116210611410.17816/CS67654276600Investigation of triiodothyronine, thyroxine, and thyroid-stimulating hormone levels’ influence on atrial myocardial electrical instability in experimental hypothyroidismRuslan F. Rakhmatullov0https://orcid.org/0000-0002-2157-544XRenata E. Dementeva1https://orcid.org/0000-0003-1497-5338Alina E. Sheina2https://orcid.org/0000-0002-9373-7268Kristina P. Kondrateva3https://orcid.org/0000-0002-8540-2054Fagim K. Rakhmatullov4https://orcid.org/0000-0002-2587-8325Ludmila V. Melnikova5https://orcid.org/0000-0003-4688-1272Penza State UniversityPenza State UniversityPenza State UniversityPenza State UniversityPenza State UniversityRussian Medical Academy of Continuous Professional EducationBACKGROUND: Identifying the association between thyroid dysfunction and the development of nonvalvular atrial fibrillation (AF) remains one of the complex and pressing issue in contemporary cardiology. To date, only a limited number of studies have examined the relationship between AF and the hypothalamic-pituitary-thyroid (HPT) axis, and the available findings are often contradictory. Few papers have explored the association between AF and HPT axis in experimental conditions. AIM: The work aimed to evaluate the association between AF and the HPT axis in experimental models of hypothyroidism, euthyroidism, and thyrotoxicosis in rats. METHODS: The study included 146 outbred rats. Group 1 comprised 42 rats with euthyroidism. Group 2 included 15 rats with overt thyrotoxicosis. Group 3 included 22 rats with subclinical thyrotoxicosis. Group 4 comprised 67 rats with euthyroid sick syndrome. The methods included electrocardiographic monitoring and measurement of thyroid hormone concentrations. RESULTS: The frequency of AF paroxysms was found to depend on thyroid hormone levels: under euthyroid conditions, on thyroid-stimulating hormone (β = −0.250; p 0.001) and thyroxine (β = 0.838; p = 0.012); in overt thyrotoxicosis, on thyroxine (β = 0.732; p = 0.00008) and triiodothyronine (β = 0.352; p = 0.043); and in subclinical thyrotoxicosis, on thyroxine (β = 2.1; p = 0.0002) and triiodothyronine (β = −0.970; p = 0.019). Threshold values of thyroid hormones were determined for euthyroid, subclinical, and overt thyrotoxic states. CONCLUSION: A relationship between atrial fibrillation and thyroid functional status was established.https://cardiosomatics.ru/2221-7185/article/viewFile/676542/204317atrial fibrillationthyroid function teststhyroid dysfunctionexperimental model |
| spellingShingle | Ruslan F. Rakhmatullov Renata E. Dementeva Alina E. Sheina Kristina P. Kondrateva Fagim K. Rakhmatullov Ludmila V. Melnikova Investigation of triiodothyronine, thyroxine, and thyroid-stimulating hormone levels’ influence on atrial myocardial electrical instability in experimental hypothyroidism КардиоСоматика atrial fibrillation thyroid function tests thyroid dysfunction experimental model |
| title | Investigation of triiodothyronine, thyroxine, and thyroid-stimulating hormone levels’ influence on atrial myocardial electrical instability in experimental hypothyroidism |
| title_full | Investigation of triiodothyronine, thyroxine, and thyroid-stimulating hormone levels’ influence on atrial myocardial electrical instability in experimental hypothyroidism |
| title_fullStr | Investigation of triiodothyronine, thyroxine, and thyroid-stimulating hormone levels’ influence on atrial myocardial electrical instability in experimental hypothyroidism |
| title_full_unstemmed | Investigation of triiodothyronine, thyroxine, and thyroid-stimulating hormone levels’ influence on atrial myocardial electrical instability in experimental hypothyroidism |
| title_short | Investigation of triiodothyronine, thyroxine, and thyroid-stimulating hormone levels’ influence on atrial myocardial electrical instability in experimental hypothyroidism |
| title_sort | investigation of triiodothyronine thyroxine and thyroid stimulating hormone levels influence on atrial myocardial electrical instability in experimental hypothyroidism |
| topic | atrial fibrillation thyroid function tests thyroid dysfunction experimental model |
| url | https://cardiosomatics.ru/2221-7185/article/viewFile/676542/204317 |
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