HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses

HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses

Summary: Human herpesvirus 6B (HHV-6B) belongs to the genus Roseolovirus of the betaherpesvirus subfamily, causing exanthema subitum and encephalitis. Although viral ribonucleotide reductase (RNR) is conserved in betaherpesviruses, it has lost its enzymatic activity. Human cytomegalovirus (HCMV) bel...

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Bibliographic Details
Main Authors: Mansaku Hirai, Khoir Amaliin, Jing Rin Huang, Salma Aktar, Yasuko Mori, Jun Arii
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Cell biology
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224029377
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