Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance
Abstract Artemisia argyi Lévl. et Vant. (A. argyi) leaf possesses various health promoting functions contributed by its main bioactive flavonoids. In this study, the anti-aging effect and mechanism of Artemisia argyi leaf extract (AALE) were identified using Caenorhabditis elegans (C. elegans) as a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-024-00358-8 |
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| author | Jinsong Wang Deyan Zhu Hailin Cui Yan Xu Shuyou Shang Yuanxin Miao Zhimin Xu Rong Li |
| author_facet | Jinsong Wang Deyan Zhu Hailin Cui Yan Xu Shuyou Shang Yuanxin Miao Zhimin Xu Rong Li |
| author_sort | Jinsong Wang |
| collection | DOAJ |
| description | Abstract Artemisia argyi Lévl. et Vant. (A. argyi) leaf possesses various health promoting functions contributed by its main bioactive flavonoids. In this study, the anti-aging effect and mechanism of Artemisia argyi leaf extract (AALE) were identified using Caenorhabditis elegans (C. elegans) as a model. The results showed that the AALE promoted the lifespan and stress resistance of C. elegans. It was found that the AALE boosted the expression of oxidative stress-related proteins by regulating the insulin/ IGF-1 signaling (IIS) pathway, which then activated the transcription factors DAF-16/FOXO. The results of RNA-sequence analysis indicated that the changes of genes in nematodes treated with AALE were associated with the responses against oxidative stress, cell maturation, and immune reaction, and stress. The positive results suggest that Artemisia argyi leaf could have the robust benefits for improving healthy aging as well as preventing aging-related diseases in the human body. |
| format | Article |
| id | doaj-art-3995363ade774783b34bd21c83c19ab9 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-3995363ade774783b34bd21c83c19ab92024-12-29T12:49:02ZengNature Portfolionpj Science of Food2396-83702024-12-018111110.1038/s41538-024-00358-8Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress toleranceJinsong Wang0Deyan Zhu1Hailin Cui2Yan Xu3Shuyou Shang4Yuanxin Miao5Zhimin Xu6Rong Li7Institute of Agricultural Biotechnology, Jingchu University of TechnologyInstitute of Agricultural Biotechnology, Jingchu University of TechnologyCharacteristic food function mining and comprehensive utilization research center, Jingchu University of TechnologyCharacteristic food function mining and comprehensive utilization research center, Jingchu University of TechnologySchool of Food Science and Engineering, Wuhan Polytechnic UniversityCharacteristic food function mining and comprehensive utilization research center, Jingchu University of TechnologySchool of Nutrition and Food Sciences, Louisiana State UniversityInstitute of Agricultural Biotechnology, Jingchu University of TechnologyAbstract Artemisia argyi Lévl. et Vant. (A. argyi) leaf possesses various health promoting functions contributed by its main bioactive flavonoids. In this study, the anti-aging effect and mechanism of Artemisia argyi leaf extract (AALE) were identified using Caenorhabditis elegans (C. elegans) as a model. The results showed that the AALE promoted the lifespan and stress resistance of C. elegans. It was found that the AALE boosted the expression of oxidative stress-related proteins by regulating the insulin/ IGF-1 signaling (IIS) pathway, which then activated the transcription factors DAF-16/FOXO. The results of RNA-sequence analysis indicated that the changes of genes in nematodes treated with AALE were associated with the responses against oxidative stress, cell maturation, and immune reaction, and stress. The positive results suggest that Artemisia argyi leaf could have the robust benefits for improving healthy aging as well as preventing aging-related diseases in the human body.https://doi.org/10.1038/s41538-024-00358-8 |
| spellingShingle | Jinsong Wang Deyan Zhu Hailin Cui Yan Xu Shuyou Shang Yuanxin Miao Zhimin Xu Rong Li Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance npj Science of Food |
| title | Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance |
| title_full | Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance |
| title_fullStr | Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance |
| title_full_unstemmed | Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance |
| title_short | Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance |
| title_sort | molecular mechanism of culinary herb artemisia argyi in promoting lifespan and stress tolerance |
| url | https://doi.org/10.1038/s41538-024-00358-8 |
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