Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats
Ovotransferrin, an iron-binding glycoprotein, accounting for approximately 12% of egg white protein, is a member of transferrin fam ily. Our previous studies showed that ovotransferrin stimulates the proliferation and differentiation of osteoblasts, while inhibits osteoclastogenesis and resorption a...
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Tsinghua University Press
2024-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250249 |
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| author | Nan Shang Xiaoyu Bao Michael Doschak Jianping Wu |
| author_facet | Nan Shang Xiaoyu Bao Michael Doschak Jianping Wu |
| author_sort | Nan Shang |
| collection | DOAJ |
| description | Ovotransferrin, an iron-binding glycoprotein, accounting for approximately 12% of egg white protein, is a member of transferrin fam ily. Our previous studies showed that ovotransferrin stimulates the proliferation and differentiation of osteoblasts, while inhibits osteoclastogenesis and resorption activity. The work aims to study the efficacy of orally administered ovotransferrin on the prevention of osteoporosis using ovariectomized (OVX) Sprague-Dawley rats. Oral administration of ovotransferrin showed no negative effect on body weight, food intake and organ weight. After 12-week treatment, feeding ovotransferrin at a dose of 1% (1 g ovotransferrin/100 g diet) prevented OVX-induced bone loss and maintained relatively high bone mineral density and integrated bone microarchitecture. The serum concentration of biomarkers indicating bone formation was increased in ovotransferrin administration groups, while the bone resorption biomarkers were decreased. Ovotransferrin feeding also decreased the production of serum cytokine TNF-α and IL-6, which are two stimulators for osteoclast differentiation. In addition to its direct regulatory role on bone turnover, ovotransferrin supplementation might benefit osteoporosis prevention by inhibiting adipogenesis, and regulating immune response. Our results suggested the potential application of ovotransferrin as a functional food ingredient on the prevention of osteoporosis. |
| format | Article |
| id | doaj-art-396aa83a98864ffd827db96974a64e48 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-396aa83a98864ffd827db96974a64e482025-01-10T06:56:56ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-09-011352562257210.26599/FSHW.2022.9250249Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized ratsNan Shang0Xiaoyu Bao1Michael Doschak2Jianping Wu3Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton T6G 2P5, CanadaDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton T6G 2P5, CanadaFaculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton T6G 2H5, CanadaDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton T6G 2P5, CanadaOvotransferrin, an iron-binding glycoprotein, accounting for approximately 12% of egg white protein, is a member of transferrin fam ily. Our previous studies showed that ovotransferrin stimulates the proliferation and differentiation of osteoblasts, while inhibits osteoclastogenesis and resorption activity. The work aims to study the efficacy of orally administered ovotransferrin on the prevention of osteoporosis using ovariectomized (OVX) Sprague-Dawley rats. Oral administration of ovotransferrin showed no negative effect on body weight, food intake and organ weight. After 12-week treatment, feeding ovotransferrin at a dose of 1% (1 g ovotransferrin/100 g diet) prevented OVX-induced bone loss and maintained relatively high bone mineral density and integrated bone microarchitecture. The serum concentration of biomarkers indicating bone formation was increased in ovotransferrin administration groups, while the bone resorption biomarkers were decreased. Ovotransferrin feeding also decreased the production of serum cytokine TNF-α and IL-6, which are two stimulators for osteoclast differentiation. In addition to its direct regulatory role on bone turnover, ovotransferrin supplementation might benefit osteoporosis prevention by inhibiting adipogenesis, and regulating immune response. Our results suggested the potential application of ovotransferrin as a functional food ingredient on the prevention of osteoporosis.https://www.sciopen.com/article/10.26599/FSHW.2022.9250249ovotransferrinovariectomized (ovx) ratsbone mineral densitybone microarchitecturebone resorptioninflammation |
| spellingShingle | Nan Shang Xiaoyu Bao Michael Doschak Jianping Wu Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats Food Science and Human Wellness ovotransferrin ovariectomized (ovx) rats bone mineral density bone microarchitecture bone resorption inflammation |
| title | Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats |
| title_full | Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats |
| title_fullStr | Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats |
| title_full_unstemmed | Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats |
| title_short | Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats |
| title_sort | oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats |
| topic | ovotransferrin ovariectomized (ovx) rats bone mineral density bone microarchitecture bone resorption inflammation |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250249 |
| work_keys_str_mv | AT nanshang oraladministrationofeggwhiteovotransferrinpreventsosteoporosisinovariectomizedrats AT xiaoyubao oraladministrationofeggwhiteovotransferrinpreventsosteoporosisinovariectomizedrats AT michaeldoschak oraladministrationofeggwhiteovotransferrinpreventsosteoporosisinovariectomizedrats AT jianpingwu oraladministrationofeggwhiteovotransferrinpreventsosteoporosisinovariectomizedrats |