Microbiome in prostate cancer: pathogenic mechanisms, multi-omics diagnostics, and synergistic therapies
Abstract Background Prostate cancer (PCa) is a leading cause of cancer-related deaths in men, with the microbiome emerging as a significant factor in its development and progression. Understanding the microbiome's role could provide new insights into PCa pathogenesis and treatment. Objective Th...
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| Format: | Article |
| Language: | English |
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Springer
2025-05-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-025-06187-w |
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| _version_ | 1849333829206016000 |
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| author | Chengran Wang Tianqi Dong Xin’ao Rong Yuce Yang Jianhui Mou Jiaqi Li Jianli Ge Xupeng Mu Jinlan Jiang |
| author_facet | Chengran Wang Tianqi Dong Xin’ao Rong Yuce Yang Jianhui Mou Jiaqi Li Jianli Ge Xupeng Mu Jinlan Jiang |
| author_sort | Chengran Wang |
| collection | DOAJ |
| description | Abstract Background Prostate cancer (PCa) is a leading cause of cancer-related deaths in men, with the microbiome emerging as a significant factor in its development and progression. Understanding the microbiome's role could provide new insights into PCa pathogenesis and treatment. Objective This review aims to explore the interactions between the microbiome and PCa, focusing on microbial imbalances and their effects on immune responses, inflammation, and hormone levels. It also discusses advanced research techniques and the potential for microbiome modulation in PCa management. Methods The review synthesizes current literature on the microbiome’s role in PCa, highlighting differences in microbial composition between cancerous and healthy prostate tissues. It examines techniques such as high-throughput sequencing and metagenomics and explores the mechanisms through which the microbiome influences PCa. Conclusions The review reveals substantial microbial differences in prostate tissues of PCa patients compared to healthy individuals, indicating a potential link between microbiome alterations and disease progression. It highlights the promise of microbiome-based strategies for diagnosis and treatment and underscores the need for further research into personalized, microbiome-centric approaches for PCa management. |
| format | Article |
| id | doaj-art-395a3f2d70df48faba37a2f45b33d74e |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-395a3f2d70df48faba37a2f45b33d74e2025-08-20T03:45:44ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352025-05-01151611710.1007/s00432-025-06187-wMicrobiome in prostate cancer: pathogenic mechanisms, multi-omics diagnostics, and synergistic therapiesChengran Wang0Tianqi Dong1Xin’ao Rong2Yuce Yang3Jianhui Mou4Jiaqi Li5Jianli Ge6Xupeng Mu7Jinlan Jiang8Department of’ Scientific Research Center, China-Japan Union Hospital of Jilin UniversityDepartment of’ Scientific Research Center, China-Japan Union Hospital of Jilin UniversityDepartment of’ Scientific Research Center, China-Japan Union Hospital of Jilin UniversityDepartment of’ Scientific Research Center, China-Japan Union Hospital of Jilin UniversityDepartment of’ Scientific Research Center, China-Japan Union Hospital of Jilin UniversityDepartment of’ Scientific Research Center, China-Japan Union Hospital of Jilin UniversityOrthopaedic Medical Center, The Second Hospital of Jilin UniversityDepartment of’ Scientific Research Center, China-Japan Union Hospital of Jilin UniversityDepartment of’ Scientific Research Center, China-Japan Union Hospital of Jilin UniversityAbstract Background Prostate cancer (PCa) is a leading cause of cancer-related deaths in men, with the microbiome emerging as a significant factor in its development and progression. Understanding the microbiome's role could provide new insights into PCa pathogenesis and treatment. Objective This review aims to explore the interactions between the microbiome and PCa, focusing on microbial imbalances and their effects on immune responses, inflammation, and hormone levels. It also discusses advanced research techniques and the potential for microbiome modulation in PCa management. Methods The review synthesizes current literature on the microbiome’s role in PCa, highlighting differences in microbial composition between cancerous and healthy prostate tissues. It examines techniques such as high-throughput sequencing and metagenomics and explores the mechanisms through which the microbiome influences PCa. Conclusions The review reveals substantial microbial differences in prostate tissues of PCa patients compared to healthy individuals, indicating a potential link between microbiome alterations and disease progression. It highlights the promise of microbiome-based strategies for diagnosis and treatment and underscores the need for further research into personalized, microbiome-centric approaches for PCa management.https://doi.org/10.1007/s00432-025-06187-wProstate cancerMicrobiomeDiagnosisPrognostic factorsTherapeutic targets |
| spellingShingle | Chengran Wang Tianqi Dong Xin’ao Rong Yuce Yang Jianhui Mou Jiaqi Li Jianli Ge Xupeng Mu Jinlan Jiang Microbiome in prostate cancer: pathogenic mechanisms, multi-omics diagnostics, and synergistic therapies Journal of Cancer Research and Clinical Oncology Prostate cancer Microbiome Diagnosis Prognostic factors Therapeutic targets |
| title | Microbiome in prostate cancer: pathogenic mechanisms, multi-omics diagnostics, and synergistic therapies |
| title_full | Microbiome in prostate cancer: pathogenic mechanisms, multi-omics diagnostics, and synergistic therapies |
| title_fullStr | Microbiome in prostate cancer: pathogenic mechanisms, multi-omics diagnostics, and synergistic therapies |
| title_full_unstemmed | Microbiome in prostate cancer: pathogenic mechanisms, multi-omics diagnostics, and synergistic therapies |
| title_short | Microbiome in prostate cancer: pathogenic mechanisms, multi-omics diagnostics, and synergistic therapies |
| title_sort | microbiome in prostate cancer pathogenic mechanisms multi omics diagnostics and synergistic therapies |
| topic | Prostate cancer Microbiome Diagnosis Prognostic factors Therapeutic targets |
| url | https://doi.org/10.1007/s00432-025-06187-w |
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